Int J Med Sci 2021; 18(10):2155-2161. doi:10.7150/ijms.55212 This issue

Research Paper

Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis

Min Ji Kwon1, Jeong Nam Kim1, Joon Park2,3, Yun Tai Kim2,3, Min Jae Lee4, Byung Joo Kim1✉

1. Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.
2. Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.
3. Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea.
4. College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.

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Citation:
Kwon MJ, Kim JN, Park J, Kim YT, Lee MJ, Kim BJ. Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis. Int J Med Sci 2021; 18(10):2155-2161. doi:10.7150/ijms.55212. Available from https://www.medsci.org/v18p2155.htm

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Abstract

Graphic abstract

The anti-cancer effects of Alisma canaliculatum extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cancer cell death was associated with Bcl-2, survivin and Bax level changes, and it activated caspase-3 and -9. In addition, it was involved in the activation of MAPKs and increased the reactive oxygen species (ROS). These results suggest that ACE induces apoptosis in AGS gastric cancer cells, and therefore, ACE may have the potential to treat gastric cancer.

Keywords: Alisma canaliculatum, Apoptosis, AGS, Gastric cancer.