Int J Med Sci 2021; 18(6):1449-1455. doi:10.7150/ijms.51117 This issue Cite

Research Paper

Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine

Sheng Wang, Msc#, Fang Wang, Msc#, Xiao Wang, MD, Yuxian Zhang, Msc, Lijun Song, MD

Department of Rheumatology, Qilu Hospital of Shandong University, Ji'nan 250012, Shandong, China.
#These authors contributed equally to this work.

Citation:
Wang S, Wang F, Wang X, Zhang Y, Song L. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int J Med Sci 2021; 18(6):1449-1455. doi:10.7150/ijms.51117. https://www.medsci.org/v18p1449.htm
Other styles

File import instruction

Abstract

Graphic abstract

Objectives: The present study aimed to observe the differences in creatinine clearance (Ccr) in systemic lupus erythematosus (SLE) patients with normal serum creatinine at different levels of urinary protein.

Method: The present cross-sectional study included 177 SLE patients with normal serum creatinine from Qilu Hospital of Shandong University between January 2010 and April 2020. The following data were collected: blood urea nitrogen (BUN), serum creatinine (Cr), serum total protein, serum albumin, immunoglobulin (Ig) G, IgA, IgM, complement 3, complement 4, anti-ds-DNA antibody, routine urine test, urine protein/creatinine ratio (UPCR) (g/g), and the SLE disease activity index. The estimated Ccr was calculated according to the Cockcroft formula.

Results: 123 patients were with positive urinary protein (Lupus Nephritis, LN group) and 54 patients were with negative urinary protein (Non-LN group). Compared with the Non-LN group, the LN group had higher BUN (5.76±3.22 vs. 4.78±1.58, P=0.007) and Cr (62.36±19.53 vs. 54.83±11.09, P=0.001). There was a strong correlation between the UPCR and the semi-quantitative determination of urine protein in LN patients (r=0.9583, P=0.0417). The serum creatinine levels were significantly higher in patients with urine protein 3+ (72.97±25.16) or massive proteinuria (62.32±19.66) than the other groups. Patients with urinary protein ± exhibited a significantly elevated Ccr when compared to patients with urinary protein 3+ (130.6±44.15 vs. 110.5±33.50, P=0.02), and patients with UPCR<0.15 g/g had higher Ccr than other groups and showed significantly increased Ccr compared with patients with UPCR≥0.15 g/g (132.44±21.02 vs. 115.14±35.89, P=0.007).

Conclusions: Early renal function impairment may be present in LN patients. The kidneys of LN patients with urinary protein ± or UPCR<0.15 g/g are in a state of hyperfunction.

Keywords: lupus nephritis, creatinine, creatinine clearance, protein urine, urine protein/creatinine ratio


Citation styles

APA
Wang, S., Wang, F., Wang, X., Zhang, Y., Song, L. (2021). Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. International Journal of Medical Sciences, 18(6), 1449-1455. https://doi.org/10.7150/ijms.51117.

ACS
Wang, S.; Wang, F.; Wang, X.; Zhang, Y.; Song, L. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int. J. Med. Sci. 2021, 18 (6), 1449-1455. DOI: 10.7150/ijms.51117.

NLM
Wang S, Wang F, Wang X, Zhang Y, Song L. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int J Med Sci 2021; 18(6):1449-1455. doi:10.7150/ijms.51117. https://www.medsci.org/v18p1449.htm

CSE
Wang S, Wang F, Wang X, Zhang Y, Song L. 2021. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int J Med Sci. 18(6):1449-1455.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.