Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine

Wang, Sheng; Wang, Fang; Wang, Xiao; Zhang, Yuxian; Song, Lijun

doi:10.7150/ijms.51117

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Int J Med Sci 2021; 18(6):1449-1455. doi:10.7150/ijms.51117 This issue Cite

Research Paper

Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine

Sheng Wang, Msc^#, Fang Wang, Msc^#, Xiao Wang, MD, Yuxian Zhang, Msc, Lijun Song, MD^✉

Department of Rheumatology, Qilu Hospital of Shandong University, Ji'nan 250012, Shandong, China.
#These authors contributed equally to this work.

Citation:

Wang S, Wang F, Wang X, Zhang Y, Song L. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int J Med Sci 2021; 18(6):1449-1455. doi:10.7150/ijms.51117. https://www.medsci.org/v18p1449.htm

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Abstract

Objectives: The present study aimed to observe the differences in creatinine clearance (Ccr) in systemic lupus erythematosus (SLE) patients with normal serum creatinine at different levels of urinary protein.

Method: The present cross-sectional study included 177 SLE patients with normal serum creatinine from Qilu Hospital of Shandong University between January 2010 and April 2020. The following data were collected: blood urea nitrogen (BUN), serum creatinine (Cr), serum total protein, serum albumin, immunoglobulin (Ig) G, IgA, IgM, complement 3, complement 4, anti-ds-DNA antibody, routine urine test, urine protein/creatinine ratio (UPCR) (g/g), and the SLE disease activity index. The estimated Ccr was calculated according to the Cockcroft formula.

Results: 123 patients were with positive urinary protein (Lupus Nephritis, LN group) and 54 patients were with negative urinary protein (Non-LN group). Compared with the Non-LN group, the LN group had higher BUN (5.76±3.22 vs. 4.78±1.58, P=0.007) and Cr (62.36±19.53 vs. 54.83±11.09, P=0.001). There was a strong correlation between the UPCR and the semi-quantitative determination of urine protein in LN patients (r=0.9583, P=0.0417). The serum creatinine levels were significantly higher in patients with urine protein 3+ (72.97±25.16) or massive proteinuria (62.32±19.66) than the other groups. Patients with urinary protein ± exhibited a significantly elevated Ccr when compared to patients with urinary protein 3+ (130.6±44.15 vs. 110.5±33.50, P=0.02), and patients with UPCR<0.15 g/g had higher Ccr than other groups and showed significantly increased Ccr compared with patients with UPCR≥0.15 g/g (132.44±21.02 vs. 115.14±35.89, P=0.007).

Conclusions: Early renal function impairment may be present in LN patients. The kidneys of LN patients with urinary protein ± or UPCR<0.15 g/g are in a state of hyperfunction.

Keywords: lupus nephritis, creatinine, creatinine clearance, protein urine, urine protein/creatinine ratio

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APA

Wang, S., Wang, F., Wang, X., Zhang, Y., Song, L. (2021). Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. International Journal of Medical Sciences, 18(6), 1449-1455. https://doi.org/10.7150/ijms.51117.

ACS

Wang, S.; Wang, F.; Wang, X.; Zhang, Y.; Song, L. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int. J. Med. Sci. 2021, 18 (6), 1449-1455. DOI: 10.7150/ijms.51117.

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CSE

Wang S, Wang F, Wang X, Zhang Y, Song L. 2021. Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine. Int J Med Sci. 18(6):1449-1455.

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