Int J Med Sci 2021; 18(3):846-851. doi:10.7150/ijms.50133 This issue

Research Paper

Similarities and differences between HIV and SARS-CoV-2

Francisco Illanes-Álvarez*, Denisse Márquez-Ruiz*, Mercedes Márquez-Coello, Sara Cuesta-Sancho, José Antonio Girón-González

Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain. Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA).
*These authors contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Illanes-Álvarez F, Márquez-Ruiz D, Márquez-Coello M, Cuesta-Sancho S, Girón-González JA. Similarities and differences between HIV and SARS-CoV-2. Int J Med Sci 2021; 18(3):846-851. doi:10.7150/ijms.50133. Available from

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In the last 50 years we have experienced two big pandemics, the HIV pandemic and the pandemic caused by SARS-CoV-2.

Both pandemics are caused by RNA viruses and have reached us from animals. These two viruses are different in the transmission mode and in the symptoms they generate. However, they have important similarities: the fear in the population, increase in proinflammatory cytokines that generate intestinal microbiota modifications or NETosis production by polymorphonuclear neutrophils, among others. They have been implicated in the clinical, prognostic and therapeutic attitudes.

Keywords: COVID-19, AIDS, pandemics, HIV, SARS-CoV-2