Int J Med Sci 2021; 18(3):727-735. doi:10.7150/ijms.50167 This issue


Thromboembolism in Patients with Hypertrophic Cardiomyopathy

Lu Liu, MD1, Zheng Liu, BS2, Xiaoping Chen, MD1✉, Sen He, MD, PhD1✉

1. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China
2. Nursing Department, West China School of Nursing, West China Hospital of Sichuan University, Chengdu, China
Lu Liu and Zheng Liu equally contribute to the article

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Liu L, Liu Z, Chen X, He S. Thromboembolism in Patients with Hypertrophic Cardiomyopathy. Int J Med Sci 2021; 18(3):727-735. doi:10.7150/ijms.50167. Available from

File import instruction


Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive models were estimated by several trials in HCM population but it turned out to be unsatisfactory. Based on those previous explorations, researchers tried to modify or develop novel models suitable for HCM population in thromboembolism prediction. In consideration of catastrophic advent events of thromboembolism, current guidelines have recommended life-long anticoagulant therapy after a single short AF.

Therefore, early identification of risk factors for thromboembolism, accurate risk stratification, timely preventive measures and aggressive management may help to avoid serious adverse thromboembolic events in HCM population.

Keywords: hypertrophic cardiomyopathy, thromboembolism, stroke, anticoagulant therapy, atrial fibrillation