Int J Med Sci
2020; 17(17):2673-2684.
doi:10.7150/ijms.49401 This issueCite
Research Paper
Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke
1. Clinical Epidemiology and Biostatistics Unit, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, A Coruña 2. Grupo de Investigacion Reumatologia y Salud Pública. Investigación en enfermería y cuidados de la salud. Complejo Hospitalario Universitario A Coruña (CHUAC), SERGAS, As Xubias 84, 15006 A Coruña. Universidade da Coruña (UDC) (A Coruña, España). 3. Nephrology Department, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, A Coruña 4. Department of Clinical Medicine; University Miguel Hernandez of San Juan de Alicante
✉ Corresponding author: González-Martín, Cristina. Grupo de Investigacion Reumatologia y Salud Pública. Investigación en enfermería y cuidados de la salud. Complejo Hospitalario Universitario A Coruña (CHUAC), SERGAS, As Xubias 84, 15006 A Coruña. Universidade da Coruña (UDC) (A Coruña, España). Mail: cristina.gmartines. Phone: 34981178217. Fax: 34981178212More
Citation:
Seijo-Bestilleiro R, Seoane-Pillado T, Pertega-Diaz S, González-Martín C, Valdes-Cañedo F, Balboa-Barreiro V, Fernandez-Rivera C, Alonso-Hernandez A, Cao-Vilariño M, Gil-Guillen V, Garcia-Rodriguez MT. Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke. Int J Med Sci 2020; 17(17):2673-2684. doi:10.7150/ijms.49401. https://www.medsci.org/v17p2673.htm
Background: measure the efficacy of exhaled carbon monoxide (CO) measurement plus brief advisory sessions to reduce smoking exposure and smoking behaviour in kidney transplant recipients.
Methods: Randomized, controlled, open-label clinical trial at a Spanish hospital.Smoking kidney transplant recipients giving their consent to participate were randomized to control (brief advice, n=63) or intervention group (brief advisory session plus measuring exhaled CO, n=59).
Measurements: Sociodemographic characteristics, cardiovascular risk factors, treatment, rejection episodes, infections, self-reported smoking, drug use, level of dependence and motivation to stop smoking (Fagerström's and Richmond's test) and stage of change (Prochaska and DiClemente's Stages). Efficacy was assessed at 3, 6, 9 and 12 months as: cotinine test, CO levels in exhaled air, nicotine dependence, motivational stages of change, motivation to stop smoking, pattern of tobacco use and smoking cessation rates.
Logistic regression models were computed.
Results: At 12 months of follow-up, differences were found in exhaled CO between the intervention and control group(6.1±6.8vs.10.2±9.7ppm;p=0.028). Carboxyhemoglobin levels were lower in the intervention group as well as the positive cotinine test (1.2±1.2%vs.2.0±2.4%;p=0.039),(53.4%vs.74.2%). At 12 months, intervention reduces the probability of a positive urine test by 28%.
Conclusions: Co-oximetry is a clinically relevant intervention for reduction of tobacco exposure in kidney transplant recipients.
Seijo-Bestilleiro, R., Seoane-Pillado, T., Pertega-Diaz, S., González-Martín, C., Valdes-Cañedo, F., Balboa-Barreiro, V., Fernandez-Rivera, C., Alonso-Hernandez, A., Cao-Vilariño, M., Gil-Guillen, V., Garcia-Rodriguez, M.T. (2020). Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke. International Journal of Medical Sciences, 17(17), 2673-2684. https://doi.org/10.7150/ijms.49401.
ACS
Seijo-Bestilleiro, R.; Seoane-Pillado, T.; Pertega-Diaz, S.; González-Martín, C.; Valdes-Cañedo, F.; Balboa-Barreiro, V.; Fernandez-Rivera, C.; Alonso-Hernandez, A.; Cao-Vilariño, M.; Gil-Guillen, V.; Garcia-Rodriguez, M.T. Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke. Int. J. Med. Sci. 2020, 17 (17), 2673-2684. DOI: 10.7150/ijms.49401.
NLM
Seijo-Bestilleiro R, Seoane-Pillado T, Pertega-Diaz S, González-Martín C, Valdes-Cañedo F, Balboa-Barreiro V, Fernandez-Rivera C, Alonso-Hernandez A, Cao-Vilariño M, Gil-Guillen V, Garcia-Rodriguez MT. Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke. Int J Med Sci 2020; 17(17):2673-2684. doi:10.7150/ijms.49401. https://www.medsci.org/v17p2673.htm
CSE
Seijo-Bestilleiro R, Seoane-Pillado T, Pertega-Diaz S, González-Martín C, Valdes-Cañedo F, Balboa-Barreiro V, Fernandez-Rivera C, Alonso-Hernandez A, Cao-Vilariño M, Gil-Guillen V, Garcia-Rodriguez MT. 2020. Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke. Int J Med Sci. 17(17):2673-2684.
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