1. FSPE Applied Bioenergetics Lab, University of Novi Sad, Novi Sad, Serbia. 2. Faculty of Health Sciences, University of Pecs, Pecs, Hungary.
✉ Corresponding author: Professor Sergej M. Ostojic, MD, PhD. ORCID ID: http://orcid.org/0000-0002-7270-2541; FSPE Applied Bioenergetics Lab, University of Novi Sad; Lovcenska 16, Novi Sad 21000, Serbia. Phone: (++381)-21-450-188; Fax: (++381)-21-450-199; E-mail: sergej.ostojicedu.rs.More
Citation:
Ostojic SM, Ratgeber L, Olah A, Betlehem J, Acs P. Guanidinoacetic acid deficiency: a new entity in clinical medicine?. Int J Med Sci 2020; 17(16):2544-2550. doi:10.7150/ijms.47757. https://www.medsci.org/v17p2544.htm
Guanidinoacetic acid (GAA, also known as glycocyamine or betacyamine) is a naturally-occurring derivative of glycine and a direct metabolic precursor of creatine, a key player in high-phosphate cellular bioenergetics. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion. GAA deficiency (as indicated by low serum GAA) has been reported in various conditions yet this intriguing clinical entity appears to be poorly characterized as yet, either as a primary deficit or a sequel of secondary disease. This minireview article summarizes the inherited and acquired disorders with apparent GAA deficiency and discusses a possible relevance of GAA shortfall in clinical medicine.
Ostojic, S.M., Ratgeber, L., Olah, A., Betlehem, J., Acs, P. (2020). Guanidinoacetic acid deficiency: a new entity in clinical medicine?. International Journal of Medical Sciences, 17(16), 2544-2550. https://doi.org/10.7150/ijms.47757.
ACS
Ostojic, S.M.; Ratgeber, L.; Olah, A.; Betlehem, J.; Acs, P. Guanidinoacetic acid deficiency: a new entity in clinical medicine?. Int. J. Med. Sci. 2020, 17 (16), 2544-2550. DOI: 10.7150/ijms.47757.
NLM
Ostojic SM, Ratgeber L, Olah A, Betlehem J, Acs P. Guanidinoacetic acid deficiency: a new entity in clinical medicine?. Int J Med Sci 2020; 17(16):2544-2550. doi:10.7150/ijms.47757. https://www.medsci.org/v17p2544.htm
CSE
Ostojic SM, Ratgeber L, Olah A, Betlehem J, Acs P. 2020. Guanidinoacetic acid deficiency: a new entity in clinical medicine?. Int J Med Sci. 17(16):2544-2550.
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