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Int J Med Sci 2020; 17(11):1508-1514. doi:10.7150/ijms.41812 This issue Cite

Research Paper

Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes

Hui Ouyang1, Zechen Zhou2, Qiwen Zheng2, Jun Zhang1✉

1. Department of Neuromedicine, Peking University People's Hospital, Beijing, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.

✉ Corresponding author: Jun Zhang, Department of Neuromedicine, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, China; E-mail: zhangjunedu.cn; TEL: +86 13517379562; FAX: +86 10 82236809.

Citation:
Ouyang H, Zhou Z, Zheng Q, Zhang J. Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes. Int J Med Sci 2020; 17(11):1508-1514. doi:10.7150/ijms.41812. https://www.medsci.org/v17p1508.htm
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Abstract

Aims: To investigate the interactions among narcolepsy-associated genes and reveal the pathways these genes involved through bioinformatics analyses.

Methods: The study was performed with the following steps: 1) Selected the previously discovered narcolepsy risk genes through literature review, 2) pathway enrichment analysis, and construction of gene-gene and protein-protein interaction (PPI) networks for narcolepsy.

Results: 1) GO analysis revealed the positive regulation of interferon-gamma production as the most enriched terms in biological process, and C-C chemokine receptor activity as the most enriched term in molecular function, 2) KEGG pathway enrichment analysis revealed selective enrichment of genes in cytokine-cytokine receptor interaction signaling pathways, and 3) five hub genes were identified (IFNAR1, IL10RB, DNMT1, TNFSF4 and NFATC2).

Conclusion: The bioinformatics results provide new insights into the molecular pathogenesis of narcolepsy and the identification of potential therapeutic targets for narcolepsy treatment.

Keywords: single-nucleotide polymorphisms, candidate gene, hypothalamic neurons, neurodegeneration, neurology

Citation styles

APA
Ouyang, H., Zhou, Z., Zheng, Q., Zhang, J. (2020). Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes. International Journal of Medical Sciences, 17(11), 1508-1514. https://doi.org/10.7150/ijms.41812.

ACS
Ouyang, H.; Zhou, Z.; Zheng, Q.; Zhang, J. Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes. Int. J. Med. Sci. 2020, 17 (11), 1508-1514. DOI: 10.7150/ijms.41812.

NLM
Ouyang H, Zhou Z, Zheng Q, Zhang J. Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes. Int J Med Sci 2020; 17(11):1508-1514. doi:10.7150/ijms.41812. https://www.medsci.org/v17p1508.htm

CSE
Ouyang H, Zhou Z, Zheng Q, Zhang J. 2020. Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes. Int J Med Sci. 17(11):1508-1514.

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