Int J Med Sci 2020; 17(10):1327-1332. doi:10.7150/ijms.45960 This issue


The Process of Osteoblastic Infection by Staphylococcus Aureus

Qiangqiang Wen, Feng Gu, Zhenjiang Sui, Zilong Su, Tiecheng Yu

Department of Orthopedics, First Hospital of Jilin University, Changchun 130021, Jilin, China.

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Wen Q, Gu F, Sui Z, Su Z, Yu T. The Process of Osteoblastic Infection by Staphylococcus Aureus. Int J Med Sci 2020; 17(10):1327-1332. doi:10.7150/ijms.45960. Available from

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Bone infection is difficult to cure, and relapse frequently occurs, which is a major treatment problem. One of the main reasons for the refractory and recurrent nature of bone infection is that bacteria, such as Staphylococcus aureus (S. aureus), can be internalized into osteoblasts after infecting bone tissue, thereby avoiding attack by the immune system and antibiotics. Understanding how bacteria (such as S. aureus) are internalized into osteoblasts is key to effective treatment. S. aureus is the most common pathogenic bacterium that causes bone infection. This paper reviews the literature, analyzes the specific process of osteoblastic S. aureus infection, and summarizes specific treatment strategies to improve bone infection treatment.

Keywords: Osteoblastic, Infection, Staphylococcus Aureus, Antimicrobial Peptides