Int J Med Sci 2020; 17(8):1015-1022. doi:10.7150/ijms.40131 This issue Cite

Research Paper

Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells

Hsiao-Chun Liu1,2,*, Chien-Chuan Chiang3,4,*, Ching-Hsiang Lin5,6,*, Chien-Sheng Chen5,6, Chyou-Wei Wei2, Shu-Yu Lin2, Giou-Teng Yiang5,6✉, Yung‑Luen Yu3,4,7,8✉

1. Department of Nursing, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
2. Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan
3. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
4. enter for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
5. Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
6. Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
7. Drug Development Center, China Medical University, Taichung 404, Taiwan
8. Department of Biotechnology, Asia University, Taichung 413, Taiwan
*Contributed equally

Citation:
Liu HC, Chiang CC, Lin CH, Chen CS, Wei CW, Lin SY, Yiang GT, Yu Y. Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int J Med Sci 2020; 17(8):1015-1022. doi:10.7150/ijms.40131. https://www.medsci.org/v17p1015.htm
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Abstract

Guava extracts purified from leaf and bark have many bio-active molecules with anti-cancer activities. In addition, lycopene-rich extracts obtained from red guava fruit can induce apoptosis in estrogen receptor-positive breast cancers. Triple-negative breast cancer (TNBC) lacks estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) and, therefore, hormone therapy and targeted therapy are not used in the clinic. The purpose of this study was to determine whether red guava fruit extracts can affect the proliferation of TNBC cells. In this study, cell viability was determined by using the MTT assay. Apoptosis and necrosis were analyzed using flow cytometry. Cleaved caspase-3 and PARP were analyzed by western blotting. We found that red guava extracts can, through caspase-3 activation and PARP cleavage signaling, induce apoptotic and necrotic death in TNBC cells. Our results thus show the therapeutic benefit of red guava extracts as a potential cancer treatment for TNBC in combination with doxorubicin or targeted therapy.

Keywords: Red guava, Triple-negative breast cancer, Apoptosis, Necrosis


Citation styles

APA
Liu, H.C., Chiang, C.C., Lin, C.H., Chen, C.S., Wei, C.W., Lin, S.Y., Yiang, G.T., Yu, Y. (2020). Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. International Journal of Medical Sciences, 17(8), 1015-1022. https://doi.org/10.7150/ijms.40131.

ACS
Liu, H.C.; Chiang, C.C.; Lin, C.H.; Chen, C.S.; Wei, C.W.; Lin, S.Y.; Yiang, G.T.; Yu, Y. Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int. J. Med. Sci. 2020, 17 (8), 1015-1022. DOI: 10.7150/ijms.40131.

NLM
Liu HC, Chiang CC, Lin CH, Chen CS, Wei CW, Lin SY, Yiang GT, Yu Y. Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int J Med Sci 2020; 17(8):1015-1022. doi:10.7150/ijms.40131. https://www.medsci.org/v17p1015.htm

CSE
Liu HC, Chiang CC, Lin CH, Chen CS, Wei CW, Lin SY, Yiang GT, Yu Y. 2020. Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int J Med Sci. 17(8):1015-1022.

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