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Int J Med Sci 2019; 16(12):1621-1630. doi:10.7150/ijms.38502 This issue Cite

Research Paper

Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae

Seong-Ho Ok1,6#, Soo Hee Lee2#, Ji-Yoon Kim3, Hyun-Jin Kim4,5, Sung Il Bae3, Yeran Hwang3, Seongyeong Tak3, Ju-Tae Sohn2,6✉

1. Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon, 51427, Republic of Korea;
2. Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 beon-gil, Jinju-si, Gyeongsangnam-do, 52727, Republic of Korea;
3. Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 beon-gil, Jinju-si, Gyeongsangnam-do, 52727, Republic of Korea;
4. Division of Applied Life Sciences (BK21 plus), Gyeongsang National University, Gyeongsang, Republic of Korea;
5. Department of Food Science & Technology, Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongsang, Republic of Korea;
6. Institute of Health Sciences, Gyeongsang National University, Jinju-si, 52727, Republic of Korea.
#These authors contributed equally to the work.

✉ Corresponding author: Ju-Tae Sohn, Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 79 Gangnam-ro, Jinju-si, 52727, Republic of Korea. E-mail: jtsohnac.kr; Tel.: +82-55-750-8586; Fax: +82-55-750-8142

Citation:
Ok SH, Lee SH, Kim JY, Kim HJ, Bae SI, Hwang Y, Tak S, Sohn JT. Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae. Int J Med Sci 2019; 16(12):1621-1630. doi:10.7150/ijms.38502. https://www.medsci.org/v16p1621.htm
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Abstract

The goal of this study was to examine the effect of lipid emulsion on the vasodilation induced in isolated endothelium-denuded rat aortae by a toxic dose of amlodipine. We examined the effects of lipid emulsion and verapamil on amlodipine-induced vasodilation. We also examined the effects of a mixture of lipid emulsion and amlodipine, as well as the centrifuged aqueous extract (CAE) obtained by ultracentrifuging such a mixture and then removing the upper lipid layer, on amlodipine-induced vasodilation. The effect of lipid emulsion on the amlodipine concentration was examined. Lipid emulsion attenuated amlodipine-induced vasodilation in isolated aortae. Both CAE and lipid emulsion containing amlodipine inhibited amlodipine-induced vasodilation. However, there was no significant difference in amlodipine-induced vasodilation between aortae treated with CAE and those treated with lipid emulsion containing amlodipine. Verapamil inhibited amlodipine-induced vasodilation. Lipid emulsion decreased the concentration of amlodipine. Lipid emulsion attenuated the vasodilation induced by a toxic amlodipine dose in NaF-precontracted aortae. The data show that lipid emulsion inhibited the vasodilation induced by a toxic amlodipine dose in isolated rat aortae by reducing the concentration of amlodipine. Amlodipine-induced vasodilation seems to be mediated mainly by blockade of L-type calcium channels and partially by inhibition of the Rho-kinase pathway.

Keywords: amlodipine, lipid emulsion, centrifuged aqueous extract, vasodilation, verapamil

Citation styles

APA
Ok, S.H., Lee, S.H., Kim, J.Y., Kim, H.J., Bae, S.I., Hwang, Y., Tak, S., Sohn, J.T. (2019). Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae. International Journal of Medical Sciences, 16(12), 1621-1630. https://doi.org/10.7150/ijms.38502.

ACS
Ok, S.H.; Lee, S.H.; Kim, J.Y.; Kim, H.J.; Bae, S.I.; Hwang, Y.; Tak, S.; Sohn, J.T. Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae. Int. J. Med. Sci. 2019, 16 (12), 1621-1630. DOI: 10.7150/ijms.38502.

NLM
Ok SH, Lee SH, Kim JY, Kim HJ, Bae SI, Hwang Y, Tak S, Sohn JT. Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae. Int J Med Sci 2019; 16(12):1621-1630. doi:10.7150/ijms.38502. https://www.medsci.org/v16p1621.htm

CSE
Ok SH, Lee SH, Kim JY, Kim HJ, Bae SI, Hwang Y, Tak S, Sohn JT. 2019. Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae. Int J Med Sci. 16(12):1621-1630.

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