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Int J Med Sci 2019; 16(5):665-674. doi:10.7150/ijms.32971 This issue Cite

Research Paper

Risk Factors of Intraoperative Dysglycemia in Elderly Surgical Patients

Cornelia Knaak¹, Tobias Wollersheim^1,2, Rudolf Mörgeli¹, Claudia Spies¹ , Gerald Vorderwülbecke¹, Victoria Windmann¹, Sophia Kuenz¹, Maryam Kurpanik¹, Gunnar Lachmann^1,2 on behalf of the BIOCOG Consortium

1. Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, D-13353 Berlin, Germany
2. Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Str. 2, D-10178 Berlin, Germany

✉ Corresponding author: Prof. Dr. Claudia Spies, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, D-13353 Berlin, Germany. Phone: +49 30 450 551 102 More

Abstract

BACKGROUNDː Dysglycemia is associated with adverse outcome including increased morbidity and mortality in surgical patients. Acute insulin resistance due to the surgical stress response is seen as a major cause of so-called stress hyperglycemia. However, understanding of factors determining blood glucose (BG) during surgery is limited. Therefore, we investigated risk factors contributing to intraoperative dysglycemia.

METHODSː In this subgroup investigation of the BIOCOG study, we analyzed 87 patients of ≥ 65 years with tight intraoperative BG measurement every 20 min during elective surgery. Dysglycemia was defined as at least one intraoperative BG measurement outside the recommended target range of 80-150 mg/dL. Additionally, all postoperative BG measurements in the ICU were obtained. Multivariable logistic regression analysis adjusted for age, sex, American Society of Anesthesiologists (ASA) status, diabetes, type and duration of surgery, minimum Hemoglobin (Hb) and mean intraoperative norepinephrine use was performed to identify risk factors of intraoperative dysglycemia.

RESULTSː 46 (52.9%) out of 87 patients developed intraoperative dysglycemia. 31.8% of all intraoperative BG measurements were detected outside the target range. Diabetes [OR 9.263 (95% CI 2.492, 34.433); p=0.001] and duration of surgery [OR 1.005 (1.000, 1.010); p=0.036] were independently associated with the development of intraoperative dysglycemia. Patients who experienced intraoperative dysglycemia had significantly elevated postoperative mean (p<0.001) and maximum BG levels (p=0.001). Length of ICU (p=0.007) as well as hospital stay (p=0.012) were longer in patients with dysglycemia.

CONCLUSIONSː Diabetes and duration of surgery were confirmed as independent risk factors for intraoperative dysglycemia, which was associated with adverse outcome. These patients, therefore, might require intensified glycemic control. Increased awareness and management of intraoperative dysglycemia is warranted.

Keywords: Intraoperative dysglycemia, hyperglycemia and hypoglycemia, diabetes, risk factors, time-in-target range

Introduction

Perioperative dysglycemia is frequently seen and associated with postoperative morbidity and mortality [1-3]. Impaired immune function, increased risk of postoperative infections, acute kidney injury, delayed wound healing, postoperative delirium and impaired cognition are recognized as adverse outcomes related to intraoperative hyperglycemia [3-10]. Hypoglycemia is known to contribute to poor postoperative outcome including cardiac arrhythmias, postoperative delirium, increased ICU stay and overall mortality, as well [11-13]. Acute insulin resistance is seen as a major cause of intraoperative hyperglycemia due to the surgical stress response enhancing the release of catecholamines and cortisol [14, 15], which can result in so-called stress hyperglycemia [16]. Associated increased glucose variability induces oxidative stress and may also negatively impact patients' recovery [17, 18]. Intraoperative hypoglycemia frequently occurs in response to intensified insulin therapy (IIT). Accordingly, IIT protocols during surgery have produced different results on clinical outcome: While Gandhi et al. [19] and Saager et al. [20] found increased incidences of stroke and delirium; Kwon et al. [21] demonstrated reduced infection and mortality rates.

In fact, evidence suggests that glucose variability resulting in both hyper- and hypoglycemia rather than either hyper- and hypoglycemia alone is critical to clinical outcome, at least in ICU patients [22, 23]. Targeting glucose levels reduced morbidity and mortality from sepsis in critically ill patients as reported by van den Berghe et al. [24]. Despite the recognition of adverse outcome associated with dysglycemia, understanding of underlying causes of intraoperative dysglycemia is limited. In this subgroup investigation of the BIOCOG study, we aimed to identify risk factors contributing to intraoperative dysglycemia to describe potential causes for glycemic derangement during surgery.

Materials and methods

Study population

This subgroup investigation of the Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BIOCOG) study (ethics EA2/092/14, clinicaltrials.gov: NCT02265263, www.biocog.eu) aimed to investigate risk factors of intraoperative dysglycemia in non-cardiac elderly patients. The BIOCOG study is a prospective multicenter observational study to develop biomarkers for risk prediction of postoperative cognitive impairment by assessment of parameters such as clinical, molecular and imaging data [25]. Patients were eligible if at least 65 years of age and if anticipated time of surgery was ≥ 60 min. Patients with a preexisting diagnosis of diabetes as well as non-diabetic patients were included. For the purpose of this subgroup investigation, a subgroup (“SugarCog”) of 89 patients enrolled at the site Charité - Universitätsmedizin Berlin between February and December 2016 obtained tight intraoperative blood glucose (BG) measurements every 20 min. These patients were preoperatively planned to receive an arterial catheter for clinical reasons such as anticipated high blood loss or need for continuous monitoring of blood pressure. All patients received guideline-based anesthesiological and surgical treatment according to our standard operating procedures (SOP) [26].

The objective of the study was to identify risk factors for intraoperative dysglycemia. In addition, we investigated the association of intraoperative and postoperative dysglycemia, the association of intraoperative dysglycemia on postoperative outcome, and whether time-out-of-target-range rather than maximum levels are associated with postoperative mortality.

Measurement of intraoperative blood glucose levels

BG levels were intraoperatively measured immediately after establishment of an arterial catheter after anesthesia induction and then regularly every 20 min until extubation. BG levels measured until up to 1 hour after extubation were considered as intraoperative data. If the patient was not extubated immediately after surgery, BG levels were measured until the patient was transferred to the ICU. All arterial blood gas analyses (ABG) were performed by ABL800 FLEX Radiometer. Dysglycemia was defined according to our SOP as BG levels outside the recommended target range of 80-150 mg/dL [26]. Patients were subsequently categorized into normoglycemia (80-150 mg/dL) and dysglycemia (at least one intraoperative measurement outside the target range). Minimum, mean and maximum BG levels were determined. Glycemic variability was calculated as the standard deviation of all available intraoperative measurements. Additionally, we determined minutes out of target range from begin until end of surgery.

Determination of postoperative blood glucose levels

Postoperative BG levels were abstracted from patients' electronic ICU charts. We included ICU measurements only as BG was assessed at regular time intervals as opposed to non-ICU-patients where BG assessment was performed infrequently and at irregular intervals. The same criteria as for intraoperative dysglycemia were applied to all postoperative BG measurements.

Perioperative inflammatory markers

C-reactive protein (CRP) levels obtained within clinical routine were abstracted from patients´ charts. CRP values preoperatively and on postoperative day 1 were compared to investigate a relationship between the inflammatory state and dysglycemia.

Clinical outcome parameters

Postoperative complications were documented up to hospital discharge and retrospectively classified according to the Clavien-Dindo classification [27]. For further analyses, we considered Clavien-Dindo grade I-II as minor and grade ≥III as major complications [28]. Length of ICU stay, time until hospital discharge and 90-day mortality were obtained.

Statistical analysis

Results are expressed as median (25%; 75% quartiles), or n frequencies (%), respectively. Differences between groups were tested using non-parametric exact Mann-Whitney-U test for continuous parameters and exact Chi-Square-test for qualitative data. To quantify surgical time-out-of-target range, we calculated the ratio of time outside the target range from begin until end of surgery. Multivariable logistic regression analysis was performed to identify factors associated with intraoperative dysglycemia. Age, sex, American Society of Anesthesiologists (ASA) status (II versus ≥III), diabetes, type (intra-abdominal/-thoracic versus other) and duration of surgery, minimum intraoperative hemoglobin (Hb) as well as mean rate of norepinephrine over anesthesia time were entered into the final model. A detailed list of types of surgeries depicts Supplement Table S1. Odds ratios (OR) with 95%-confidence intervals (CI) and the corresponding p-values were calculated for each risk factor. In a post-hoc approach, the most predictive time point for dysglycemia to occur was determined by a receiver operating characteristics (ROC) curve. Between-group differences regarding postoperative glycemic profiles and clinical outcome were assessed by univariate testing, i.e. exact non-parametric Mann-Whitney-U test and exact Chi-Square-test, respectively. In addition, using the exact Mann-Whitney-U test, maximum BG levels and time-out-of-target range were compared between survivors and non-survivors 90 days after surgery, in order to test for differences in intraoperative dysglycemia.

For the purpose of this exploratory subgroup investigation, no a priori sample size calculation was performed. All results have to be understood in the area of purely exploratory data analysis. No adjustments for multiple testing have been made and p-values do not allow for confirmatory generalization of results. A two-tailed p-value <0.05 was considered statistically significant. Analyses were carried out using IBM© SPSS© Statistics (version 25) and The R Project for Statistical Computing (version 3.4.1).

Ethics

Ethical approval was obtained (Ethikkommission der Charité - Universitätsmedizin Berlin, EA2/092/14). All patients gave written informed consent upon enrolment. The study complied with the Declaration of Helsinki.

Results

Study population

Of 89 patients included in this subgroup investigation, 87 had a prospectively investigated tight intraoperative BG measurement and were, thus, included in the final analysis (Figure 1). Of these, 58 also had at least one postoperative BG measurement by clinical staff due to admission to the ICU. All patients received general anesthesia. One patient required mechanical ventilation due to hypothermia after the end of surgery and was extubated in the ICU 5 hours later. All other patients were extubated immediately after end of surgery. 1354 BG levels were intraoperatively measured [15 (9; 21) per patient]. 31.8% of all measured BG levels were outside the target range of 80-150 mg/dL (Figure 2). 1309 BG levels were postoperatively obtained [13 (6; 28) per patient]. Over all patients, intraoperative minimum and maximum BG was 64 mg/dL and 325 mg/dL, respectively. Postoperatively, minimum and maximum BG was 53 mg/dL and 357 mg/dL, respectively.

Intraoperative dysglycemia occurred in 46 out of 87 patients (52.9%). Table 1 demonstrates the distribution of patient baseline characteristics, intra- and postoperative variables between patients with intraoperative dysglycemia and those within target range. Patients with dysglycemia had significantly more often a primary diagnosis of diabetes mellitus and had a longer duration of surgery.

Risk factors for intraoperative dysglycemia

Adjusting for age, sex, ASA status, diabetes, type and duration of surgery, minimum Hb as well as intraoperative mean rate of norepinephrine over anesthesia time, multivariable logistic regression revealed only diabetes and duration of surgery as independently associated with dysglycemia (Table 2). In a post-hoc approach, plotting of the ROC curve revealed a surgical time of 134 min most predictive for dysglycemia to occur (sensitivity 71.7%, specificity 63.4%, AUC 0.678, p=0.004). Course of intraoperative BG levels between diabetic and non-diabetic patients is shown in Figure 3.

Patients with intraoperative dysglycemia showed increased postoperative maximum glucose levels

High incidences of postoperative dysglycemia were seen in both groups (Table 3). Patients with intraoperative dysglycemia showed increased postoperative maximum (p=0.001) and mean BG levels (p<0.001). Postoperative dysglycemia occurred in 18 patients (46.2%) who experienced intraoperative dysglycemia but had no previous diagnosis of diabetes.

 Figure 1 

− Consort diagram.

 Figure 2 

− Histogram of all 1354 intraoperative blood glucose measurements.

 Figure 3 

Time course of intraoperative blood glucose levels between diabetic and non-diabetic patients. Eleven out of 27 (40.7%) diabetic patients received intraoperative insulin (median 8 IU (4; 18)) while 7 out of 60 (11.7%) non-diabetic patients were treated with intraoperative insulin (median 12 IU (4; 14)). For reasons of comparability between diabetic and non-diabetic patients, measurements exceeding 300 min are not shown to maintain > 5 measurements per group. First time point was measured immediately after anesthesia induction when the arterial catheter was established. Plotted curves indicate median BG values; grey bands reflect 95% confidence intervals of the respective group.

Intraoperative dysglycemia was associated with adverse clinical outcome

No differences were seen in terms of postoperative complications with regard to Clavien-Dindo classification (Table 1). However, dysglycemic patients had a significantly longer ICU (p=0.007) as well as hospital LOS (p=0.012). When differentiating between patients with and without preexisting diabetes, those who experienced dysglycemia without diabetes (n=25) showed a trend towards higher mortality rates compared to patients with both diabetes and intraoperative dysglycemia (n=21) [deceased 8 (32.0%) versus 2 (9.5%); p=0.084)].

Discussion

This study is the first to investigate risk factors for the development of intraoperative dysglycemia in a mixed surgical cohort. The primary finding of this study is that diabetes and duration of surgery were associated with intraoperative dysglycemia independent of age, sex, ASA status, type of surgery, minimum Hb and mean norepinephrine rate over anesthesia time. A surgical time of at least 134 min was most predictive for developing intraoperative dysglycemia. Furthermore, dysglycemic patients were at higher risk for postoperative hyperglycemia and adverse postoperative outcome. Importantly, only two patients experienced hypoglycemia whereas hyperglycemia was detected in 45 patients including one with both hypo- and hyperglycemia. Consequently, hyper- rather than hypoglycemia challenges intraoperative BG management. However, both require attention as hypoglycemia might ensue from overtreatment of hyperglycemia.

To the moment, extent rather than duration of surgery has been considered a major contributor to perioperative hyperglycemia [10]. Clarke et al. [29] found major surgery to be associated with more severe dysglycemia reasoning that extended surgical trauma leads to increased inflammation and subsequently to a more pronounced stress response. However, our results indicate that duration rather than the extent of surgery contributes to dysglycemia, suggesting that surgical time is critical to progress of the inflammatory response. Subsequently, insulin resistance in response to surgical stress and its related inflammatory process might be aggravated over time, thereby underscoring the key role of time in the development of dysglycemic states.

Even though intraoperative dysglycemia likely occurred in response to inflammatory stress, no difference between patients with dysglycemia and those without was seen in CRP levels neither preoperatively nor 1 day after surgery. As demonstrated by Thorell et al. [30], cytokine release, as one component of the surgical stress response, is related to reduced insulin sensitivity. The authors reported a relationship between increased IL-6 plasma concentrations and a decrease in insulin sensitivity. However, those findings were limited to the postoperative period. Yet, others detected an IL-6 increase early during surgery suggesting that IL-6 mediated insulin resistance increases BG levels over time [31]. This holds important implications for intraoperative BG management. Strategies to control the inflammatory stress response might be considered in order to reduce stress hyperglycemia. Although no difference with regard to dysglycemia was seen in our cohort between patients with and without epidural anesthesia, its use has been demonstrated to reduce the neuroendocrine stress response [32]. An effect similar to that of dexmedetomidine was shown by Shamim et al. [33]. They reported an attenuated stress response in patients receiving dexmedetomidine during laparascopic pyeloplasty. Patients treated with dexmedetomidine had significantly lower levels of serum cortisol and BG. Besides measures to prevent intraoperative hyperglycemia, monitoring its development is of particular concern. Given that the development of dysglycemia is related to surgical time, intensified glycemic control is justified with increasing length of surgery. Anesthesiologists should be aware of the increased risk for dysglycemia suggesting intensified BG monitoring, at least in increased surgical time. Detecting dysglycemia at an early time point allows for adequate therapy. Since dysglycemia is an adverse event for which treatment is easily available, i.e. administering of either insulin or glucose, prevention by thorough monitoring should be the objective of intraoperative BG management.

In our analysis, the critical time for dysglycemia to occur was after 134 minutes. Of note, 31.8% of all BG measurements lay outside the target range. Although BG was monitored closely in this cohort and appropriate therapy was available, glucose concentrations outside the target range remained high. These findings point out an underestimation of intraoperative dysglycemia. Therefore, close BG measurement needs to be included into clinical routine while dysglycemia should be treated immediately.

Patients with a known diagnosis of diabetes were at higher risk to develop intraoperative dysglycemia. It is acknowledged that diabetic patients demonstrate higher BG levels intraoperatively [34]. Yet, Masla et al. [35] found no difference in intraoperative BG levels between diabetic and non-diabetic patients undergoing coronary artery bypass grafting (CABG). However, this might be due to the fact that the authors assessed BG every 30 minutes only during bypass time. Alterations in BG during on-pump CABG might differ from those occurring during non-cardiac surgery.

Diabetic patients are less likely to experience adverse postoperative outcome compared to non-diabetic patients with dysglycemia [2, 36]. This might reflect adaption to higher BG levels in that diabetic patients can cope inflammatory and oxidative stress [2, 37]. In consequence, different BG target ranges might be recommended for patients with diabetes while patients without diabetes benefit from early intervention to prevent damage from acute hyperglycemia [37]. The fact that intraoperative dysglycemia was related to elevated BG maximum levels in the postoperative period indicates that intraoperatively acquired imbalances influence metabolic homeostasis after surgery. These findings suggest that intraoperative stress hyperglycemia might persist in the postoperative period also in non-diabetic patients. Nair et al. [38] reported similar findings showing that intraoperative elevated mean glucose levels were associated with elevated postoperative levels. Consequently, it can be assumed that intraoperatively dysglycemic patients are at high risk to develop hyperglycemia postoperatively. The recognition that dysglycemia developing intraoperatively is related to postoperative hyperglycemia which itself is a predictor for increased morbidity and mortality, warrants preventive strategies for dysglycemia. Furthermore, in patients with dysglycemia, tight glycemic control should be maintained during the postoperative period to avoid adverse outcomes [21, 39]. In future studies, it will also be of interest to investigate whether a history of dysglycemia related to surgery in non-diabetic patients is associated with an increased risk to develop diabetes mellitus.

In the clinical context of surgical ICU patients, it has been acknowledged that targeting BG levels within a prespecified range improves clinical outcome [24, 40]. However, data on the impact of intraoperative glycemic control and the association of intraoperative and postoperative dysglycemia in non-cardiac patients remain scarce [38]. Gandhi et al. identified intraoperative hyperglycemia as a predictor for adverse outcome including increased mortality after cardiac surgery [41]. A trial conducted by the same research group investigating the influence of intraoperative insulin therapy revealed no reduction in postoperative morbidity but rather an increase of death and stroke related to tight glycemic control, which was attributed to hypoglycemia after insulin therapy [19]. These findings contrast those of Bláha et al. [34] who reported a reduction in postoperative complications when comparing intraoperative tight glucose control to postoperative initiation supporting the concept of glucose target control.

In our study population of 87 patients, dysglycemia was seen in 46 (52.9%) patients of which 21 (45.7%) had a known diagnosis of diabetes indicating that in more than 50% of all cases, dysglycemia developed in patients without a previous diagnosis of diabetes, which is well described as stress hyperglycemia [16]. In previous studies, differences occurred in patients with diabetes and those without, although both experience an increase in glucose levels in response to surgical stress [42]. However, stress hyperglycemia in non-diabetics leads to a relatively higher rise in BG levels affecting coagulation and immune function and increasing the risk for adverse cardiovascular events [5, 43, 44]. Consequently, in the critically ill without known diabetes, hyperglycemia has deleterious effects on outcome including survival, whereas patients with diabetes seem to be less affected [45, 46]. This is consistent with our finding: Non-diabetics with dysglycemia showed increased 90-day mortality. These protective effects of chronic hyperglycemia on acute hyperglycemia have been attributed to a downregulation of glucose transporters protecting tissues from glucose toxicity [37]. Langouche et al. demonstrated reduced inflammatory activation of the endothelium as a result of insulin therapy providing a rationale for insulin administration to maintain euglycemia [47]. Yet, complete understanding of the pathophysiology of stress hyperglycemia requires further investigation.

Since dysglycemia can be diagnosed during surgery, and should, thus, be preventable if recognized in time, a concept of a standardized protocol for intraoperative glycemic control is warranted. However, in order to target intraoperative BG levels, the underlying factors of dysglycemia need to be identified. We hereby hope to contribute to a better understanding of the development of dysglycemia.

This study has obvious limitations. First, our sample size of 87 patients aged ≥ 65 years limits generalizability to different patient groups. Second, we did not assess insulin resistance nor was continuous glucose monitoring available. Particularly insulin resistance as underlying pathophysiology might be of great interest in further studies. Third, total blood loss was not assessed and could not be adjusted for in regression analysis. Given that blood loss may also indicate surgical stress, BG levels could also have been influenced. Fourth, no marker indicating intraoperative inflammation was available to support the pathobiology of prolonged inflammation leading to the development of dysglycemia. Only CRP measurements were obtained pre- and postoperatively which are insufficient to assess the inflammatory response in the perioperative period. Finally, survival data were only obtained until day 90 after surgery limiting long-term follow-up.

Conclusions

The duration of surgery and preexisting diabetes were confirmed as independent risk factors for the occurrence of intraoperative dysglycemia, while age, sex, ASA status, type of surgery, minimum Hb and norepinephrine had no influence. These patients were also at risk for severe postoperative hyperglycemia and adverse outcome. Further studies are warranted to identify preventive strategies such as tight glycemic control.

Supplementary Material

Supplementary tables.

Acknowledgements

The research leading to these results has received funding from the European Union Seventh Framework Program [FP7/2007-2013] under grant agreement n° 602461. Gunnar Lachmann and Tobias Wollersheim are participants of the Clinician Scientist Program granted by the Berlin Institute of Health (BIH). We acknowledge support from the German Research Foundation (DFG) and the Open Access Publication Fund of the Charité - Universitätsmedizin Berlin.

Authors' contributions

Conceived and designed the experiments: TW, CS, GL. Performed the experiments: CK, TW, RM, VW, SK, MK, GL. Analysed the data: CK, GV, VW, GL. Wrote the manuscript: CK, VW, GL.

Competing Interests

The authors have declared that no competing interest exists.

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Corresponding author: Prof. Dr. Claudia Spies, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, D-13353 Berlin, Germany. Phone: +49 30 450 551 102

Received 2019-1-9
Accepted 2019-3-23
Published 2019-5-10

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