Int J Med Sci 2019; 16(4):513-518. doi:10.7150/ijms.29750 This issue


Circular RNAs: Novel Promising Biomarkers in Ocular Diseases

Nan Guo1*, Xiu-fen Liu1*, Om Prakash Pant1*, Dan-Dan Zhou2*, Ji-long Hao1✉, Cheng-wei Lu1✉

1. Department of Ophthalmology,
2. Department of Radiology, The First Hospital of Jilin University, No. 71 of xinmin St., Changchun, Jilin Province, 130021, China.
*Nan Guo, Xiu-fen Liu, Om Prakash Pant, Dan-Dan Zhou are co-first authors.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Guo N, Liu Xf, Pant OP, Zhou DD, Hao Jl, Lu Cw. Circular RNAs: Novel Promising Biomarkers in Ocular Diseases. Int J Med Sci 2019; 16(4):513-518. doi:10.7150/ijms.29750. Available from

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Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs produced by back-splicing. They are found to be expressed in eukaryotic cells and play certain roles in various cellular functions, including fibrosis, cell proliferation, differentiation, apoptosis and angiogenesis. Dysregulated circRNAs are found in several human disorders including, malignancy, vascular, inflammatory as well as nervous diseases. Although, increasing evidence suggests that circRNAs may also contribute in different ocular diseases, the outline of circRNAs in ocular diseases remains obscure. In this review we consider the current state of knowledge regarding the potential role and underlying mechanism of circRNAs in ocular diseases including pterygium, age-related cataract, glaucoma, diabetic retinopathy, retinoblastoma, retinal vascular dysfunction and hyperhomocysteinemia induced ocular diseases, emphasizing that circRNAs could be promising biomarkers for the diagnosis and prognosis evaluation. Future circRNAs-targeted intervention may become a novel therapeutic tool for the treatment of ocular diseases.

Keywords: circRNAs, non-coding RNAs, ocular diseases