Int J Med Sci 2018; 15(4):403-410. doi:10.7150/ijms.23150 This issue


Cardiovascular Adaptations Induced by Resistance Training in Animal Models

S.F.S. Melo1,2, N.D. da Silva Júnior2, V.G. Barauna1, E.M. Oliveira2✉

1. Laboratory of Molecular Physiology, Health Sciences Center, Federal University of Espírito Santo. Address: Av. Marechal Campos, 1468 Maruípe, Espírito Santo, Vitória, Brazil. Postal code: 29043900. Telephone number: (5527)996892407.
2. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of São Paulo. Address: Av. Prof. Mello Moraes, 65, Cidade Universitária, São Paulo, São Paulo, Brazil. Postal code: 05508-9000. Telephone number: (5511) 30913136.

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Melo SFS, da Silva Júnior ND, Barauna VG, Oliveira EM. Cardiovascular Adaptations Induced by Resistance Training in Animal Models. Int J Med Sci 2018; 15(4):403-410. doi:10.7150/ijms.23150. Available from

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In the last 10 years the number of studies showing the benefits of resistance training (RT) to the cardiovascular system, have grown. In comparison to aerobic training, RT-induced favorable adaptations to the cardiovascular system have been ignored for many years, thus the mechanisms of the RT-induced cardiovascular adaptations are still uncovered. The lack of animal models with comparable protocols to the RT performed by humans hampers the knowledge. We have used squat-exercise model, which is widely used by many others laboratories. However, to a lesser extent, other models are also employed to investigate the cardiovascular adaptations. In the subsequent sections we will review the information regarding cardiac morphological adaptations, signaling pathway of the cardiac cell, cardiac function and the vascular adaptation induced by RT using this animal model developed by Tamaki et al. in 1992. Furthermore, we also describe cardiovascular findings observed using other animal models of RT.

Keywords: resistance training, cardiovascular adaptation, animal model