Int J Med Sci 2018; 15(3):210-216. doi:10.7150/ijms.22517 This issue

Research Paper

Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes

Yujie Liu1, Yunpeng Wu1, Yanmin Wang2, Mo Zhang1, Zhili Li1✉

1. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, PR China
2. Department of Clinical Laboratory, Heze Municipal Hospital, Shandong 274031, PR China

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Liu Y, Wu Y, Wang Y, Zhang M, Li Z. Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes. Int J Med Sci 2018; 15(3):210-216. doi:10.7150/ijms.22517. Available from

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Objective: To screen novel biomarkers in the levels of protein complexes for type 2 diabetes mellitus (T2DM).

Methods: Serum immunoinflammation-related protein complexes (IIRPCs) and diabetes-related protein complexes (DRPCs) in 1537 serum samples including 504 healthy controls, 320 patients with prediabetes, and 713 patients with T2DM were analyzed using an optimized native polyacrylamide gel electrophoresis (native-PAGE).

Results: Seven patterns of serum IIRPCs and four patterns of serum DRPCs were observed in the study population, respectively. Significant increase in the levels of serum IIRPCs in T2DM was detected relative to healthy controls. Change trends of serum DRPCs are as below: patients with T2DM>patients with prediabetes> healthy controls.

Conclusion: Our findings suggest that increased levels of serum IIRPCs and DRPCs were associated with T2DM.

Keywords: protein complex, diabetes-related protein complex, type 2 diabetes