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Int J Med Sci 2017; 14(7):690-697. doi:10.7150/ijms.19124 This issue Cite

Research Paper

Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population

Yang Song1, 3, Zhen-wu Du1,2,3, Qi-wei Yang2, 3, Ming Ren1, 2, Qing-yu Wang2, 3, Ao Wang1, 3, Gao-yang Chen2, 3, Hai-yue Zhao2, 3, Tao Yu1, 2✉, Gui-zhen Zhang1,2,3✉

1. Department of Orthopedics of Second Clinical College, Jilin University, Changchun, 130041, China;
2. Research Center of Second Clinical College, Jilin University, Changchun, 130041, China;
3. The Engineering Research Center of Molecular Diagnosis and Cell Treatment for Metabolic Bone Diseases of Jilin Province, Changchun, 130041, China.

✉ Corresponding authors: Tao Yu M.D. and Ph.D. Department of Orthopedics of Second Clinical College of Jilin University, Changchun, 130041, China. Tel.: 86-431-88796301; Fax: 86-431-88796301 Email: yutaojlucom; Gui-zhen Zhang M.D. and Ph.D., Depa More

Citation:
Song Y, Du Zw, Yang Qw, Ren M, Wang Qy, Wang A, Chen Gy, Zhao Hy, Yu T, Zhang Gz. Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population. Int J Med Sci 2017; 14(7):690-697. doi:10.7150/ijms.19124. https://www.medsci.org/v14p0690.htm
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Abstract

The RANKL/RANK/OPG pathway plays an important role in regulating bone remodeling and bone turnover. However, the association of the genes variants with the risk of ONFH has rarely been reported. Here, we analyzed the correlation of the 10 SNPs polymorphisms of RANKL, RANK, OPG, TRAF6, and NFATC1 genes with the risk and development of ONFH in 200 ONFH patients and 177 health controls of Chinese population with using Mass ARRAY® platform. The results showed that the recessive model of NFATC1rs9518 was significantly associated with increased ONFH risk (OR:8.223, P=0.048); the proportion of stage Ⅳ patients in the rs9518TC genotype carriers was statistically higher than that of stage Ⅲ patients (P=0.03); in the T-C haplotype carriers of Naftac1, the proportion of bilateral hips lesions was also significantly enhanced than that of unilateral hip lesions(P=0.05). In addition, the proportion of idiopathic ONFH in the TT genotype carriers of OPGrs2073617 was significantly higher than that of steroid or alcohol-induced ONFH, respectively, while in the TC genotype carriers of the SNP, the proportion of idiopathic ONFH remarkably decreased compared with that of Alcohol-induced ONFH, P=0.021. Our results were first found that NFATC1rs9518 closely associated with the risk and the development of ONFH, while OPGrs2073617 statistically correlated with the etiological classification of ONFH.

Keywords: ONFH, gene polymorphism, RANKL/RANK/OPG pathway, TRAF6, NFATC1.

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APA
Song, Y., Du, Z.w., Yang, Q.w., Ren, M., Wang, Q.y., Wang, A., Chen, G.y., Zhao, H.y., Yu, T., Zhang, G.z. (2017). Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population. International Journal of Medical Sciences, 14(7), 690-697. https://doi.org/10.7150/ijms.19124.

ACS
Song, Y.; Du, Z.w.; Yang, Q.w.; Ren, M.; Wang, Q.y.; Wang, A.; Chen, G.y.; Zhao, H.y.; Yu, T.; Zhang, G.z. Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population. Int. J. Med. Sci. 2017, 14 (7), 690-697. DOI: 10.7150/ijms.19124.

NLM
Song Y, Du Zw, Yang Qw, Ren M, Wang Qy, Wang A, Chen Gy, Zhao Hy, Yu T, Zhang Gz. Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population. Int J Med Sci 2017; 14(7):690-697. doi:10.7150/ijms.19124. https://www.medsci.org/v14p0690.htm

CSE
Song Y, Du Zw, Yang Qw, Ren M, Wang Qy, Wang A, Chen Gy, Zhao Hy, Yu T, Zhang Gz. 2017. Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population. Int J Med Sci. 14(7):690-697.

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