Int J Med Sci 2016; 13(11):835-840. doi:10.7150/ijms.16563 This issue


The Limbal Epithelial Progenitors in the Limbal Niche Environment

Yuan Zhang1*, Hong Sun2*, Yongsong Liu3, Shuangling Chen1, Subo Cai4, Yingting Zhu1, Ping Guo5✉

1. Research and Development Department, TissueTech, Inc., 7000 SW 97th Avenue, Suite 212, Miami, FL 33173, USA
2. Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
3. Department of Ophthalmology, Yan' An Hospital of Kunming City, Kunming, 650051, China
4. Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
5. Shenzhen Eye Hospital, School of Optometry & Ophthalmology of Shenzhen University, Shenzhen Key Laboratory of Department of Ophthalmology, Shenzhen, 518000, China
*The first two authors contributed equally to this manuscript.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Zhang Y, Sun H, Liu Y, Chen S, Cai S, Zhu Y, Guo P. The Limbal Epithelial Progenitors in the Limbal Niche Environment. Int J Med Sci 2016; 13(11):835-840. doi:10.7150/ijms.16563. Available from

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Limbal epithelial progenitors are stem cells located in limbal palisades of vogt. In this review, we present the audience with recent evidence that limbal epithelial progenitors may be a powerful stem cell resource for the cure of human corneal stem cell deficiency. Further understanding of their mechanism may shed lights to the future successful application of stem cell therapy not only to the eye tissue, but also to the other tissues in the human body.

Keywords: Limbal epithelial progenitors, stem cell