Int J Med Sci 2016; 13(9):696-700. doi:10.7150/ijms.16259 This issue Cite

Research Paper

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy

Cheng-Hsueh Lee1,2, Jiunn-Bey Pao3, Te-Ling Lu4, Hong-Zin Lee4, Yung-Chin Lee1,5, Chia-Chu Liu1,5, Chao-Yuan Huang6, Victor C. Lin7,8, Chia-Cheng Yu9,10, Hsin-Ling Yin11,12, Shu-Pin Huang1,2,5✉, Bo-Ying Bao4,13,14✉

1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
3. Department of Pharmacy, Linsen Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan;
4. Department of Pharmacy, China Medical University, Taichung, Taiwan;
5. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
6. Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;
7. Department of Urology, E-Da Hospital, Kaohsiung, Taiwan;
8. School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan;
9. Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;
10. Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan;
11. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
12. Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
13. Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan;
14. Department of Nursing, Asia University, Taichung, Taiwan.

Citation:
Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY. Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. Int J Med Sci 2016; 13(9):696-700. doi:10.7150/ijms.16259. https://www.medsci.org/v13p0696.htm
Other styles

File import instruction

Abstract

Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.

Methods: We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy.

Results: One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis.

Conclusion: Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients.

Keywords: biochemical recurrence, prostate cancer, radical prostatectomy, single-nucleotide polymorphism, PTGS2, inflammation.


Citation styles

APA
Lee, C.H., Pao, J.B., Lu, T.L., Lee, H.Z., Lee, Y.C., Liu, C.C., Huang, C.Y., Lin, V.C., Yu, C.C., Yin, H.L., Huang, S.P., Bao, B.Y. (2016). Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. International Journal of Medical Sciences, 13(9), 696-700. https://doi.org/10.7150/ijms.16259.

ACS
Lee, C.H.; Pao, J.B.; Lu, T.L.; Lee, H.Z.; Lee, Y.C.; Liu, C.C.; Huang, C.Y.; Lin, V.C.; Yu, C.C.; Yin, H.L.; Huang, S.P.; Bao, B.Y. Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. Int. J. Med. Sci. 2016, 13 (9), 696-700. DOI: 10.7150/ijms.16259.

NLM
Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY. Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. Int J Med Sci 2016; 13(9):696-700. doi:10.7150/ijms.16259. https://www.medsci.org/v13p0696.htm

CSE
Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY. 2016. Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. Int J Med Sci. 13(9):696-700.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image