Int J Med Sci
2016; 13(5):325-329.
doi:10.7150/ijms.14849 This issueCite
Research Paper
Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study
Tarja Kunnas, Kirsi Määttä, Seppo T Nikkari✉
Department of Medical Biochemistry, University of Tampere Medical School and Fimlab laboratories, Tampere, Finland.
✉ Corresponding author: Seppo Nikkari, MD, PhD, Department of Medical Biochemistry, University of Tampere Medical School, 33014 University of Tampere, Finland. Phone: +358 50 3969 639; E-mail: seppo.nikkarifi.
Citation:
Kunnas T, Määttä K, Nikkari ST. Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. Int J Med Sci 2016; 13(5):325-329. doi:10.7150/ijms.14849. https://www.medsci.org/v13p0325.htm
Oxidative stress is involved in the pathophysiology of many cardiovascular disorders, such as hypertension and atherosclerosis. NRF2 is the primary transcriptional regulator of several antioxidant genes, including that of sulfiredoxin (SRXN1). The association of genotypes of NRF2 and SRXN1 with cardiovascular conditions was studied in a Finnish cohort of 336 subjects with diagnosed hypertension and 480 normotensive controls from the Tampere adult population cardiovascular risk study (TAMRISK). Samples were genotyped for four SNPs (rs1962142, rs2706110, rs6721961 and rs6706649) in the NRF2 gene region and four SNPs (rs6053666, rs6116929, rs2008022, rs6085283) in the SRXN1 gene region using Competitive Allele Specific PCR (KASP) technique. Cardiovascular diseases were followed up from 2005 to 2014 using the Finnish National Hospital Discharge Registry (HILMO). Four out of eight studied polymorphisms: rs6721961, rs1962142, rs2706110 of NRF2, and rs6053666 of SRXN1 were associated with cerebrovascular disease. NRF2 polymorphism rs6721961 showed association with hypertension. NRF2 and SRXN1 polymorphisms, previously thought to be associated with human disease, appear to be associated particularly with cerebrovascular disease.
Keywords: NF-E2-Related Factor 2/genetics, Genetic Predisposition to Disease/genetics, Oxidoreductases Acting on Sulfur Group Donors/genetics, Cerebrovascular Disorders.
Citation styles
APA
Kunnas, T., Määttä, K., Nikkari, S.T. (2016). Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. International Journal of Medical Sciences, 13(5), 325-329. https://doi.org/10.7150/ijms.14849.
ACS
Kunnas, T.; Määttä, K.; Nikkari, S.T. Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. Int. J. Med. Sci. 2016, 13 (5), 325-329. DOI: 10.7150/ijms.14849.
NLM
Kunnas T, Määttä K, Nikkari ST. Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. Int J Med Sci 2016; 13(5):325-329. doi:10.7150/ijms.14849. https://www.medsci.org/v13p0325.htm
CSE
Kunnas T, Määttä K, Nikkari ST. 2016. Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. Int J Med Sci. 13(5):325-329.