Association of Salivary <i>Helicobacter pylori</i> Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population

Ding, Yi-Jian; Yan, Tian-Lian; Hu, Xin-Lan; Liu, Jian-Hua; Yu, Chao-Hui; Li, You-Ming; Wang, Qun-Yan

doi:10.7150/ijms.11050

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Int J Med Sci 2015; 12(9):742-747. doi:10.7150/ijms.11050 This issue Cite

Research Paper

Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population

Yi-Jian Ding^1,†, Tian-Lian Yan^2,†, Xin-Lan Hu³, Jian-Hua Liu¹, Chao-Hui Yu², You-Ming Li², Qun-Yan Wang^2,✉

1. Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
3. Department of Stomatology, Red Corss Hospital, Hangzhou 310003, China
^† Both authors contributed equally to this work.

Citation:

Ding YJ, Yan TL, Hu XL, Liu JH, Yu CH, Li YM, Wang QY. Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population. Int J Med Sci 2015; 12(9):742-747. doi:10.7150/ijms.11050. https://www.medsci.org/v12p0742.htm

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Abstract

Objective: The aim of this study was to detect the prevalence of oral H.pylori among adults and to investigate the correlation between H.pylori infection and common oral diseases.

Study design: A cross-sectional study was performed among adults Chinese who took their annual oral healthy examination at The First Affiliated Hospital, Zhejiang University School of Medicine, China.

Results: The study included 1050 subjects in total and oral H.pylori infection occurred in 60.29% of the subjects. The prevalence rates of oral H.pylori in patients with periodontal diseases (63.42%) and caries (66.91%) were significantly increased than those without oral diseases (54.07%), respectively (P < 0.05), while the difference between subjects with recurrent aphthous stomatitis and controls was not significant. In addition, the differences of positive rates of H.pylori with or without history of gastric ulcer were statistically significant (69.47% vs 58.26%, P<0.05). Presenting with periodontal diseases (OR 1.473;95% CI 1.021 to 2.124), caries (OR 1.717; 1.127 to 2.618), and having history of gastric ulcer (OR 1.631; 1.164 to 2.285) increased the risk of H.pylori infection.

Conclusions: Oral H.pylori infection is common in adult Chinese, which is significantly associated with oral diseases including periodontal diseases and caries.

Keywords: Helicobacter pylori, saliva H.pylori antigen test, caries, periodontal diseases, recurrent aphthous stomatitis

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APA

Ding, Y.J., Yan, T.L., Hu, X.L., Liu, J.H., Yu, C.H., Li, Y.M., Wang, Q.Y. (2015). Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population. International Journal of Medical Sciences, 12(9), 742-747. https://doi.org/10.7150/ijms.11050.

ACS

Ding, Y.J.; Yan, T.L.; Hu, X.L.; Liu, J.H.; Yu, C.H.; Li, Y.M.; Wang, Q.Y. Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population. Int. J. Med. Sci. 2015, 12 (9), 742-747. DOI: 10.7150/ijms.11050.

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CSE

Ding YJ, Yan TL, Hu XL, Liu JH, Yu CH, Li YM, Wang QY. 2015. Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population. Int J Med Sci. 12(9):742-747.

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