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Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761 This issue Cite

Short Research Communication

Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

Paola Aulino1,2#, Alessandra Costa1,3,4#, Ernesto Chiaravalloti2, Barbara Perniconi2,5, Sergio Adamo1, Dario Coletti2,5, Massimo Marrelli2, Marco Tatullo2,6#✉, Laura Teodori3,7#

1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy
3. Fondazione San Raffaele, Ceglie Messapica, Italy
4. Department of Surgery, McGowan Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
5. UMR 8256 CNRS Biology of Adaptation and Aging, University Pierre et Marie Curie Paris 06, Paris, France
6. Tecnologica Research Institute, Biomedical Section, Crotone, Italy
7. UTAPRAD-DIM, ENEA Frascati, Rome, Italy
# These authors equally contributed.

✉ Corresponding author: Dr. Marco Tatullo, PhD, Scientific Director - Tecnologica Research Institute, St. E. Fermi - Crotone, Italy. Phone: 0962-930362; Fax: 0962930362; E-mail: marco.tatullocom

Citation:
Aulino P, Costa A, Chiaravalloti E, Perniconi B, Adamo S, Coletti D, Marrelli M, Tatullo M, Teodori L. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761. https://www.medsci.org/v12p0336.htm
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Abstract

The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.

Keywords: ECM scaffold, tissue engineering, skeletal muscle, bone, cartilage

Citation styles

APA
Aulino, P., Costa, A., Chiaravalloti, E., Perniconi, B., Adamo, S., Coletti, D., Marrelli, M., Tatullo, M., Teodori, L. (2015). Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. International Journal of Medical Sciences, 12(4), 336-340. https://doi.org/10.7150/ijms.10761.

ACS
Aulino, P.; Costa, A.; Chiaravalloti, E.; Perniconi, B.; Adamo, S.; Coletti, D.; Marrelli, M.; Tatullo, M.; Teodori, L. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int. J. Med. Sci. 2015, 12 (4), 336-340. DOI: 10.7150/ijms.10761.

NLM
Aulino P, Costa A, Chiaravalloti E, Perniconi B, Adamo S, Coletti D, Marrelli M, Tatullo M, Teodori L. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761. https://www.medsci.org/v12p0336.htm

CSE
Aulino P, Costa A, Chiaravalloti E, Perniconi B, Adamo S, Coletti D, Marrelli M, Tatullo M, Teodori L. 2015. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int J Med Sci. 12(4):336-340.

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