Int J Med Sci 2014; 11(7):658-662. doi:10.7150/ijms.8331 This issue

Research Paper

Oxycodone vs. Fentanyl Patient-Controlled Analgesia after Laparoscopic Cholecystectomy

Boo-Young Hwang, Jae-Young Kwon, Eunsoo Kim, Do-Won Lee, Tae-Kyun Kim, Hae-Kyu Kim

Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

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Hwang BY, Kwon JY, Kim E, Lee DW, Kim TK, Kim HK. Oxycodone vs. Fentanyl Patient-Controlled Analgesia after Laparoscopic Cholecystectomy. Int J Med Sci 2014; 11(7):658-662. doi:10.7150/ijms.8331. Available from

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Objectives Oxycodone is semi-synthetic opioid, oral and parenteral preparations have been widely used for acute and chronic pain. The aim of this study was to assess the efficacy and side effects of oxycodone and fentanyl in patient controlled analgesia (PCA) after laparoscopic cholecystectomy.

Methods A prospective, randomized, double-blind study was conducted. 81 patients were randomly divided into two groups; fentanyl (10 mcg fentanyl and 1.5 mg ketorolac) and oxycodone group (1 mg oxycodone and 1.5 mg ketorolac). After the operation, a blinded observer assessed pain using a numerical rating scale (NRS), infused PCA dose, side effects, sedation levels, and satisfaction.

Results Cumulative PCA dose of oxycodone group at 48 h (31.4 ± 16.0 ml) was significantly less than that of fentanyl group (43.8 ± 23.1 ml, P = 0.009). Oxycodone group showed more nausea at 6 - 24 h after the operation (P = 0.001), but there was no difference in satisfaction score (P = 0.073). There were no significant differences in other side effects, sedation and NRS scores between two groups.

Conclusion Oxycodone showed comparable effects for pain relief compared to fentanyl in spite of less cumulative PCA dose. Based on these results, we could conclude that oxycodone may be useful as an alternative to fentanyl for PCA after laparoscopic cholecystectomy.

Keywords: Fentanyl, Laparoscopic cholecystectomy surgery, Oxycodone, Patient-controlled analgesia, Postoperative pain.