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Int J Med Sci 2014; 11(6):646-651. doi:10.7150/ijms.8577 This issue Cite

Research Paper

Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders

Akinobu Maeda1, Kouichi Tamura1✉, Hiromichi Wakui1, Masato Ohsawa1, Kengo Azushima1, Kazushi Uneda1, Ryu Kobayashi1, Yuko Tsurumi-Ikeya1, Tomohiko Kanaoka1, Toru Dejima1, Koji Ohki1, Sona Haku1, Akio Yamashita2, Satoshi Umemura1

1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
2. Department of Molecular Biology, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

✉ Corresponding author: Kouichi Tamura, MD, PhD, Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Phone: +81 45 787 2635; Fax: +81 45 701 More

Citation:
Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Kanaoka T, Dejima T, Ohki K, Haku S, Yamashita A, Umemura S. Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders. Int J Med Sci 2014; 11(6):646-651. doi:10.7150/ijms.8577. https://www.medsci.org/v11p0646.htm
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Abstract

Recent studies indicate that the functional renin-angiotensin system (RAS) exists in the adipose tissue. The adipose tissue RAS is proposed in the pathophysiology of metabolic disorders. In the present study, we examined therapeutic effects of irbesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy mice, a model of human metabolic disorders without any dietary loading, with our focus on the analysis on possible effect of irbesartan on the adipose tissue. The treatment with irbesartan significantly lowered systolic blood pressure with a concomitant decrease in body weight in KKAy mice. In addition, irbesartan significantly decreased the adipose leptin mRNA expression and tended to decrease IL-6 mRNA expression in the adipose tissue of KKAy mice. Furthermore irbesartan preserved the adipose gene expression of AT1R-associated protein (ATRAP), an endogenous inhibitory molecule of tissue AT1R signaling, with a concomitant tendency of up-regulation of adipose tissue ATRAP/AT1R ratio. Collectively, these results suggest that the irbesartan-induced beneficial suppressive effect on the leptin-IL-6 axis in the adipose tissue in KKAy mice is partly mediated by a trend of up-regulation of the adipose ATRAP/AT1R ratio as one of pleiotropic effects of irbesartan.

Keywords: adipose tissue, metabolic disorders, inflammation, receptor, renin-angiotensin system.

Citation styles

APA
Maeda, A., Tamura, K., Wakui, H., Ohsawa, M., Azushima, K., Uneda, K., Kobayashi, R., Tsurumi-Ikeya, Y., Kanaoka, T., Dejima, T., Ohki, K., Haku, S., Yamashita, A., Umemura, S. (2014). Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders. International Journal of Medical Sciences, 11(6), 646-651. https://doi.org/10.7150/ijms.8577.

ACS
Maeda, A.; Tamura, K.; Wakui, H.; Ohsawa, M.; Azushima, K.; Uneda, K.; Kobayashi, R.; Tsurumi-Ikeya, Y.; Kanaoka, T.; Dejima, T.; Ohki, K.; Haku, S.; Yamashita, A.; Umemura, S. Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders. Int. J. Med. Sci. 2014, 11 (6), 646-651. DOI: 10.7150/ijms.8577.

NLM
Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Kanaoka T, Dejima T, Ohki K, Haku S, Yamashita A, Umemura S. Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders. Int J Med Sci 2014; 11(6):646-651. doi:10.7150/ijms.8577. https://www.medsci.org/v11p0646.htm

CSE
Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Kanaoka T, Dejima T, Ohki K, Haku S, Yamashita A, Umemura S. 2014. Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders. Int J Med Sci. 11(6):646-651.

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