Int J Med Sci 2013; 10(5):624-633. doi:10.7150/ijms.5779 This issue

Research Paper

Clinical Effects of Xinmailong Therapy in Patients with Chronic Heart Failure

Qilin Ma2, Youxi Luo1, Pi Guo1,3, Gan Gao2, Meixue Yang1, Gaurav Sablok4, Yanchun Zhang5,6, Fengfeng Zhou1,✉

1. Shenzhen Institutes of Advanced Technology, and Key Laboratory of Health Informatics, Chinese Academy of Sciences, Shenzhen, Guangdong, P.R. China, 518055;
2. Cardiovascular Internal Department, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410008;
3. Department of Public Health, Shantou University Medical College, No. 22 Xinling Road, Shantou, Guangdong, P.R. China, 515041;
4. Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38010 S. Michele all'Adige (TN), Italy.
5. Centre for Applied Informatics, College of Engineering and Science, Victoria University, PO Box 14428, Melbourne , VIC 8001, Australia.
6. Centre for Ficticious Economy and Data Science, University of Chinese Academy of Science. #305, Building 6, Zhongguancun East Road 80, Haidian District , Beijing, China 100190.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Ma Q, Luo Y, Guo P, Gao G, Yang M, Sablok G, Zhang Y, Zhou F. Clinical Effects of Xinmailong Therapy in Patients with Chronic Heart Failure. Int J Med Sci 2013; 10(5):624-633. doi:10.7150/ijms.5779. Available from

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In the last 100 years, intensive studies have been done on the identification of the systematic approaches to find the cure for the chronic heart failure, however the mystery remains unresolved due to its complicated pathogenesis and ineffective early diagnosis. The present investigation was aimed to evaluate the potential effects of the traditional chinese medicine, Xinmailong, on the chronic heart failure (CHF) patients as compared to the standard western medical treatment available so far. In our study, we selected two groups of voluntary CHF patients at the Xiangya Hospital, which were allowed to administrate Xinmailong or standard treatments, respectively. Another group of voluntary healthy individuals were recruited as the control group. The treatment effectiveness was measured by five symptomatic factors, i.e. angiotensin II (Ang_II), high sensitivity C-reactive protein (hs_CRP), Left Ventricular End Systolic Volume Index (LVESVI), left ventricular ejection fraction (LVEF) and pro-B-type natriuretic peptide (NT_proBNP), between the control group and the CHF patients at different stages of drug administration and in different treatment groups. The timeline for the full dose administration was set to 15 days and five measurements as indicated above were taken on every 0, 7th and 15th day of the drug administration respectively. In the conducted study, similar symptomatic measurements were observed on day 0 in both treatment groups, and slight improvements were observed on 7th day. It was observed that after a full course of drug administration for 15 days, both of the treatment groups achieved statistically significant improvements in all the five measures, but Xinmailong was found to be more (almost double) statistically significant as compared with the available drug treatments for chronic heart failure.

Keywords: Chronic heart failure, Traditional Chinese Medicine, Xinmailong.