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Int J Med Sci 2011; 8(7):540-546. doi:10.7150/ijms.8.540 This issue Cite

Research Paper

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Yuksel DOGAN^1✉, Aliye SOYLU², Gulay A. EREN³, Sule POTUROGLU⁴, Can DOLAPCIOGLU⁵, Kenan SONMEZ⁶, Habibe DUMAN⁷, Isa SEVINDIR⁷

1. Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey
2. Department of Gastroenterology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey
3. Department of Intensive Care, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey
4. Department of Gastroenterology, Haseki Education and Research Hospital, Istanbul, Turkey
5. Department of Gastroenterology, Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey
6. Department of Cardiology, Kosuyolu Heart and Research Hospital, Istanbul, Turkey
7. Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey

✉ Corresponding author: Yuksel Dogan, M.D., Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Cardiology Department, Istanbul, Turkey. Phone: +90 212 414 75 11, Fax: +90 212 583 77 57, Gsm: +90 542 242 02 33, E-mail: yukseldogancom More

Abstract

Background: In inflammatory bowel disease (IBD) number of thromboembolic events are increased due to hypercoagulupathy and platelet activation. Increases in mean platelet volume (MPV) can lead to platelet activation, this leads to thromboembolic events and can cause acute coronary syndromes. In IBD patients, QT-dispersion and P-wave dispersion are predictors of ventricular arrhythmias and atrial fibrilation; MPV is accepted as a risk factor for acute coronary syndromes, we aimed at evaluating the correlations of these with the duration of disease, its localization and activity.

Methods: The study group consisted of 69 IBD (Ulcerative colitis n: 54, Crohn's Disease n:15) patients and the control group included 38 healthy individuals. Disease activity was evaluated both endoscopically and clinically. Patients with existing cardiac conditions, those using QT prolonging medications and having systemic diseases, anemia and electrolyte imbalances were excluded from the study. QT-dispersion, P-wave dispersion and MPV values of both groups were compared with disease activity, its localization, duration of disease and the antibiotics used.

Results: The P-wave dispersion values of the study group were significantly higher than those of the control group. Duration of the disease was not associated with QT-dispersion, and MPV levels. QT-dispersion, P-wave dispersion, MPV and platelet count levels were similar between the active and in mild ulcerative colitis patients. QT-dispersion levels were similar between IBD patients and the control group. No difference was observed between P-wave dispersion, QT-dispersion and MPV values; with regards to disease duration, disease activity, and localization in the study group (p>0.05).

Conclusions: P-wave dispersion which is accepted as a risk factor for the development of atrial fibirilation was found to be high in our IBD patients. This demonstrates us that the risk of developing atrial fibrillation may be high in patients with IBD. No significant difference was found in the QT-dispersion, and in the MPV values when compared to the control group.

Keywords: Inflammatory bowel diseases, QT-dispersion, P-wave dispersion, mean platelet volume

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