Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease

Cebi, Aysegul; Kaya, Yuksel; Gungor, Hasan; Demir, Halit; Yoruk, Ibrahim Hakki; Soylemez, Nihat; Gunes, Yilmaz; Tuncer, Mustafa

doi:10.7150/ijms.8.456



Theranostics

International Journal of Biological Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

Full Text | PDF

Int J Med Sci 2011; 8(6):456-460. doi:10.7150/ijms.8.456 This issue Cite

Research Paper

Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease

Aysegul Cebi^1✉, Yuksel Kaya², Hasan Gungor³, Halit Demir⁴, Ibrahim Hakki Yoruk⁴, Nihat Soylemez², Yilmaz Gunes⁵, Mustafa Tuncer⁵

1. Giresun University Faculty of Health Sciences, Giresun, Turkey
2. Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Van, Turkey
3. Mus State Hospital, Department of Cardiology, Mus, Turkey
4. Yuzuncu Yil University Faculty of Science, Department of Chemistry, Van, Turkey
5. Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, Van, Turkey

Citation:

Cebi A, Kaya Y, Gungor H, Demir H, Yoruk IH, Soylemez N, Gunes Y, Tuncer M. Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease. Int J Med Sci 2011; 8(6):456-460. doi:10.7150/ijms.8.456. https://www.medsci.org/v08p0456.htm

Other styles

Abstract

Aim: In the present study, we aimed to assess serum concentrations of zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), lead (Pb), manganese (Mn), vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) in patients with coronary artery disease (CAD) and to compare with healthy controls.

Methods: A total of 30 CAD patients and 20 healthy subjects were included in this study. Atomic absorption spectrophotometry (UNICAM-929) was used to measure heavy metal and trace element concentrations. Serum α-tocopherol, retinol and cholecalciferol were measured simultaneously by high performance liquid chromatography (HPLC).

Results: Demographic and baseline clinical characteristics were not statistically different between the groups. Serum concentrations of retinol (0.3521±0.1319 vs. 0.4313±0.0465 mmol/I, p=0.013), tocopherol (3.8630±1.3117 vs. 6.9124±1.0577 mmol/I, p<0.001), cholecalciferol (0.0209±0.0089 vs. 0.0304±0.0059 mmol/I, p<0.001) and Fe (0.5664±0.2360 vs. 1.0689±0,4452 µg/dI, p<0.001) were significantly lower in CAD patients. In addition, while not statistically significant serum Cu (1.0164±0.2672 vs. 1.1934±0.4164 µg/dI, p=0.073) concentrations were tended to be lower in patients with CAD, whereas serum lead (0.1449±0.0886 vs. 0.1019±0.0644 µg/dI, p=0.069) concentrations tended to be higher.

Conclusions: Serum level of trace elements and vitamins may be changed in patients with CAD. In this relatively small study we found that serum levels of retinol, tocopherol, cholecalciferol, iron and copper may be lower whereas serum lead concentrations may be increased in patients with CAD.

Keywords: coronary artery disease, trace element, heavy metal, vitamin

Citation styles

APA

Cebi, A., Kaya, Y., Gungor, H., Demir, H., Yoruk, I.H., Soylemez, N., Gunes, Y., Tuncer, M. (2011). Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease. International Journal of Medical Sciences, 8(6), 456-460. https://doi.org/10.7150/ijms.8.456.

ACS

Cebi, A.; Kaya, Y.; Gungor, H.; Demir, H.; Yoruk, I.H.; Soylemez, N.; Gunes, Y.; Tuncer, M. Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease. Int. J. Med. Sci. 2011, 8 (6), 456-460. DOI: 10.7150/ijms.8.456.

NLM

CSE

Cebi A, Kaya Y, Gungor H, Demir H, Yoruk IH, Soylemez N, Gunes Y, Tuncer M. 2011. Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease. Int J Med Sci. 8(6):456-460.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.