Int J Med Sci 2006; 3(2):29-34. doi:10.7150/ijms.3.29 This issue


Molecular Virology of Hepatitis C Virus (HCV): 2006 Update

Volker Brass1, Darius Moradpour2, Hubert E. Blum1

1. Department of Medicine II, University of Freiburg, D-79106 Freiburg, Germany
2. Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland

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Brass V, Moradpour D, Blum HE. Molecular Virology of Hepatitis C Virus (HCV): 2006 Update. Int J Med Sci 2006; 3(2):29-34. doi:10.7150/ijms.3.29. Available from

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Fascinating progress in the understanding of the molecular biology of hepatitis C virus (HCV) was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently, recombinant infectious HCV could be produced in cell culture, rendering all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In this review, we summarize recent advances and discuss future research directions.

Keywords: helicase, hepatitis C virus, protease, polymerase, replicon