Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study

Ma, Jincheng; Liu, Dabin; Mao, Xiaodan; Huang, Leyi; Ren, Yuan; Xu, Xiaozhen; Huang, Xiaoli; Deng, Caiping; Shi, Feifeng; Sun, Pengming

doi:10.7150/ijms.91506

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Int J Med Sci 2024; 21(4):601-611. doi:10.7150/ijms.91506 This issue Cite

Research Paper

Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study

Jincheng Ma^1,2,3*, Dabin Liu^4*, Xiaodan Mao^1,2,3, Leyi Huang^1,2,3, Yuan Ren^1,2,3, Xiaozhen Xu⁵, Xiaoli Huang^6,7, Caiping Deng⁸, Feifeng Shi^5✉, Pengming Sun^1,2,3,4✉

1. Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian, China.
2. Fujian Key Laboratory of Women and Children's Critical Diseases Research, Fujian Maternity and Child Health Hospital, Fuzhou 350001, Fujian, China.
3. Fujian Clinical Research Center for Gynecological Oncology, Fujian Maternity and Child Health Hospital, Fuzhou 350001, Fujian, China.
4. Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian, China.
5. Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian, China.
6. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
7. Department of Obstetrics and Gynecology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China.
8. The Second Hospital of Nanping City, Nanping 354200, Fujian, China.
* These authors contributed equally to this work.

Citation:

Ma J, Liu D, Mao X, Huang L, Ren Y, Xu X, Huang X, Deng C, Shi F, Sun P. Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study. Int J Med Sci 2024; 21(4):601-611. doi:10.7150/ijms.91506. https://www.medsci.org/v21p0601.htm

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Abstract

Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment in patients with abnormal uterine bleeding.

Methods: In this multicenter retrospective cohort study of 287 patients with abnormal uterine bleeding, comprehensive clinical information and laboratory assessments, including cytokines, routine blood tests, and tumor markers, were performed. Associations between the clinical indicators and endometrial carcinogenesis/progression were evaluated. The independent risk factors for endometrial cancer and endometrial cancer with deep myometrial invasion were analyzed using multivariate binary logistic regression. Additionally, a diagnostic model was used to evaluate the predictive efficacy of these identified risk factors.

Results: In patients with abnormal uterine bleeding, low IL-4 and high IL-8 levels were independent risk factors for endometrial cancer (p < 0.05). Combining IL-4, IL-8, CA125, and menopausal status improved the accuracy of assessing endometrial cancer risk. The area under curve of the model is 0.816. High IL-6 and IL-8 levels were independent risk factors for deep myometrial invasion in patients with endometrial cancer (p < 0.05). Similarly, combining IL-6, IL-8, and Monocyte counts enhanced the accuracy of assessing endometrial cancer risk with deep myometrial invasion. The area under curve of the model is 0.753.

Conclusions: Cytokines such as IL-4, IL-8, and IL-6 can serve as markers for monitoring endometrial cancer and its progression in women with abnormal uterine bleeding.

Keywords: endometrial cancer, cytokine, abnormal uterine bleeding, biomarker, inflammation, predictive model.

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APA

Ma, J., Liu, D., Mao, X., Huang, L., Ren, Y., Xu, X., Huang, X., Deng, C., Shi, F., Sun, P. (2024). Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study. International Journal of Medical Sciences, 21(4), 601-611. https://doi.org/10.7150/ijms.91506.

ACS

Ma, J.; Liu, D.; Mao, X.; Huang, L.; Ren, Y.; Xu, X.; Huang, X.; Deng, C.; Shi, F.; Sun, P. Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study. Int. J. Med. Sci. 2024, 21 (4), 601-611. DOI: 10.7150/ijms.91506.

NLM

CSE

Ma J, Liu D, Mao X, Huang L, Ren Y, Xu X, Huang X, Deng C, Shi F, Sun P. 2024. Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study. Int J Med Sci. 21(4):601-611.

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