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ISSN 1449-1907
International Journal of Biological Sciences
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| Objective: The effects of dose-escalation of 5-fluorouracil (5-FU) on the clinical outcome and pharmacokinetics of 5-FU were investigated in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. Methods: Thirty-five patients with Stage III/IVa were enrolled, who were treated with a definitive 5-FU/cisplatin-based chemoradiotherapy. A course consisted of continuous infusion of 5-FU at 400 mg/m2/day (the standard dose group, N=27) or 500-550 mg/m2/day (the high dose group, N=8) for days 1-5 and 8-12, infusion of cisplatin at 40 mg/m2/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5:00 PM on days 3, 10, 38 and 45, and at 5:00 AM on days 4, 11, 39 and 46. ...details |
| Background: To identify the microorganisms that can grow rapidly in total parenteral nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions without lipid. Methods: Experiment 1: A commercial TPN solution without lipid containing multivitamins (pH5.6) was used. A specific number of each test microorganism was added to each 10 mL of the TPN solution and incubated at room temperature. ...details |
| OBJECTIVE: To identify apparent adverse effects of treatment of chronic hepatitis C and their relationship to sustained virologic response (SVR). METHODS: A retrospective study was conducted of all Hepatitis C virus (HCV)-infected patients treated with pegylated interferon and ribavirin in an academic ambulatory infectious disease practice. Clinical and laboratory characteristics were compared between patients with SVR and without SVR. RESULTS: Fifty-four patients completed therapy with the overall SVR rate of 76%. SVR was associated with genotype non-1 (P=0.01), weight loss more than 5 kilograms (P=0.04), end of treatment leukopenia ...details |
| The ligation of active pharmaceutical ingredients (API) for working with image processing systems in diagnostics (MRT) attracts increasing notice and scientific interest. The Diels-Alder ligation Reaction with inverse electron demand (DARinv) turns out to be an appropriate candidate. The DARinv is characterized by a specific distribution of electrons of the diene and the corresponding dienophile counterpart. Whereas the reactants in the classical Diels-Alder Reaction feature electron-rich diene and electron-poor dienophile compounds, the DARinv exhibits exactly the opposite distribution of electrons. Substituents with pushing electrones increase and, with pulling electrons reduce the electron density of the dienes as used in the DARinv. We report here that the DARinv is an efficient route for coupling of multifunctional molecules like active peptides, re-formulated drugs or small molecules like the alkyalting agent temozolomide (TMZ). ...details |
| Age-associated thymic involution is characterized by decreased thymopoiesis, adipocyte deposition and changes in the expression of various thymic microenvironmental factors. In this work, we characterized the distribution of fat-storing cells within the aging thymus. We found an increase of unilocular adipocytes, ERTR7+ and CCR5+ fat-storing multilocular cells in the thymic septa and parenchymal regions, thus suggesting that mesenchymal cells could be immigrating and differentiating in the aging thymus. We verified that the expression of CCR5 and its ligands, CCL3, CCL4 and CCL5, were increased in the thymus with age. Hypothesizing that the increased expression of chemokines and the CCR5 receptor may play a role in adipocyte recruitment and/or differentiation within the aging thymus, we examined the potential role for CCR5 signaling on adipocyte physiology using 3T3-L1 pre-adipocyte cell line. More ... |
Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis
Khalil Kanjwal, Beverly Karabin, Yousuf Kanjwal, Blair P Grubb
Int. J. Med. Sci. 2010, 7: 62-67
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Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk - A Meta-Analysis
Qiaoqiao Fang, Furu Wang, Deyu Zhao
Int. J. Med. Sci. 2010, 7: 55-61
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Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Kaori Kadoyama, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
Int. J. Med. Sci. 2010, 7: 48-54
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Growth of Microorganisms in Total Parenteral Nutrition Solutions Without Lipid
Takashi Kuwahara, Shinya Kaneda, Kazuyuki Shimono, Yoshifumi Inoue
Int. J. Med. Sci. 2010, 7: 43-47
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Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatment
Nuntra Suwantarat, Alan D. Tice, Thana Khawcharoenporn, Dominic C. Chow
Int. J. Med. Sci. 2010, 7: 36-42
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Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes
Valeria de Mello Coelho, Allyson Bunbury, Leticia B. Rangel, Banabihari Giri, Ashani Weeraratna, Patrice J. Morin, Michel Bernier, Dennis D. Taub
Int. J. Med. Sci. 2010, 7: 1-14
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Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome
Hirohisa Okuma, Yasuhisa Kitagawa, Takashi Yasuda, Kentaro Tokuoka, Shigeharu Takagi
Int. J. Med. Sci. 2010, 7: 15-18
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The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners
Manfred Wiessler, Waldemar Waldeck, Christian Kliem, Ruediger Pipkorn, Klaus Braun
Int. J. Med. Sci. 2010, 7: 19-28
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Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action
Bok Y. Lee, Noori AL-Waili, Dean Stubbs, Keith Wendell, Glenn Butler, Thia AL-Waili, Ali AL-Waili
Int. J. Med. Sci. 2010, 7: 29-35
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Campylobacter cholecystitis
Deepak Udayakumar, Mohammed Sanaullah
Int. J. Med. Sci. 2009, 6: 374-375
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Autofluorescent Proteins as Photosensitizer in Eukaryontes
Waldemar Waldeck, Gabriele Mueller, Manfred Wiessler, Manuela Brom, Katalin Tóth, Klaus Braun
Int. J. Med. Sci. 2009, 6: 365-373
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980 nm diode lasers in oral and facial practice: current state of the science and art
Apollonia DESIATE, Stefania CANTORE, Domenica TULLO, Giovanni PROFETA, Felice Roberto GRASSI, Andrea BALLINI
Int. J. Med. Sci. 2009, 6: 358-364
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Why are some children with early onset of asthma getting better over the years? - Diagnostic failure or salutogenetic factors
Eduardo Roel, Olle Zetterström, Erik Trell, Tomas Faresjö
Int. J. Med. Sci. 2009, 6: 348-357
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High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment
Klaus Braun, Volker Ehemann, Manfred Wiessler, Ruediger Pipkorn, Bernd Didinger, Gabriele Mueller, Waldemar Waldeck
Int. J. Med. Sci. 2009, 6: 338-347
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Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men
Jingmei Jiang, Boqi Liu, Philip C. Nasca, Wei Han, Xiaonong Zou, Xianjia Zeng, Xiaobing Tian, Yanping Wu, Ping Zhao, Junyao Li
Int. J. Med. Sci. 2009, 6: 329-337
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Foreign body aspirations in Infancy: a 20-year experience
Nader Saki, Soheila Nikakhlagh, Fakher Rahim, Hassan Abshirini
Int. J. Med. Sci. 2009, 6: 322-328
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Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial
David C. Crowley, Francis C. Lau, Prachi Sharma, Malkanthi Evans, Najla Guthrie, Manashi Bagchi, Debasis Bagchi, Dipak K. Dey, Siba P. Raychaudhuri
Int. J. Med. Sci. 2009, 6: 312-321
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Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
Int. J. Med. Sci. 2009, 6: 305-311
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