International Journal of Medical Sciences

3 September 2010

ISSN 1449-1907

International Journal of Biological Sciences

Editor-in-Chief: Dennis D. Taub, Ph.D.
Editor-in-Chief's Profile

Indexed in MEDLINE, PubMed, EMBASE, CAS/Chemical Abstracts, CAB Abstracts, Scopus, Science Citation Index (SCI) Expanded ....
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This Journal is ranked very well among the top 7.5% of journals according to SCImago in the area of Medicine ...details

Scheduled Special Issue: Palaeo Biomedicine – an evaluation of ancient medical practices and modern analytical techniques. Guest editor: Dr. Adrian Harrison, Dept. of Animal & Veterinary Basic Sciences (IBHV), Copenhagen University, Denmark.

Objective: We assessed the ability of two commercially-available fractions labeled SX and D derived from the edible maitake mushroom to overcome many age-associated metabolic perturbations such as progressive, age-related elevation of blood pressure, over activity of the renin-angiotensin system (RAS), decreased insulin sensitivity, and inflammation in an in vivo laboratory model. Design and Method: We divided forty mature, female Sprague-Dawley rats (SD) into five groups of eight. SD ingested regular rat chow containing added sucrose (20% w/w). The groups received baseline diet alone (control) or baseline diet containing captopril, niacin-bound chromium, maitake fraction SX, or maitake fraction D. In addition to blood pressure readings, the following procedures were implemented: losartan and insulin challenges, evaluation of serum ACE activity, glucose tolerance testing, blood chemistries, LNAME challenge, and measurement of various circulating cytokines.......details

Study Design: A randomized, double-blind, controlled trial. Objective: To determine the clinical effectiveness of therapeutic lumbar facet joint nerve blocks with or without steroids in managing chronic low back pain of facet joint origin. Summary of Background Data: Lumbar facet joints have been shown as the source of chronic pain in 21% to 41% of low back patients with an average prevalence of 31% utilizing controlled comparative local anesthetic blocks. Intraarticular injections, medial branch blocks, and radiofrequency neurotomy of lumbar facet joint nerves have been described in the alleviation of chronic low back pain of facet joint origin. ......details

Among the applications of fullerene technology in health sciences the expanding field of magnetic resonance imaging (MRI) of molecular processes is most challenging. Here we present the synthesis and application of a Gd_xSc_3-xN@C₈₀-BioShuttle-conjugate referred to as Gd-cluster@-BioShuttle, which features high proton relaxation and, in comparison to the commonly used contrast agents, high signal enhancement at very low Gd concentrations. This modularly designed contrast agent represents a new tool for improved monitoring and evaluation of interventions at the gene transcription level. Also, a widespread monitoring to track individual cells is possible, as well as sensing of microenvironments. .......details

Objective: The effects of dose-escalation of 5-fluorouracil (5-FU) on the clinical outcome and pharmacokinetics of 5-FU were investigated in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. Methods: Thirty-five patients with Stage III/IVa were enrolled, who were treated with a definitive 5-FU/cisplatin-based chemoradiotherapy. A course consisted of continuous infusion of 5-FU at 400 mg/m²/day (the standard dose group, N=27) or 500-550 mg/m²/day (the high dose group, N=8) for days 1-5 and 8-12, infusion of cisplatin at 40 mg/m²/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5:00 PM on days 3, 10, 38 and 45, and at 5:00 AM on days 4, 11, 39 and 46. ...details

OBJECTIVE: To identify apparent adverse effects of treatment of chronic hepatitis C and their relationship to sustained virologic response (SVR). METHODS: A retrospective study was conducted of all Hepatitis C virus (HCV)-infected patients treated with pegylated interferon and ribavirin in an academic ambulatory infectious disease practice. Clinical and laboratory characteristics were compared between patients with SVR and without SVR. RESULTS: Fifty-four patients completed therapy with the overall SVR rate of 76%. SVR was associated with genotype non-1 (P=0.01), weight loss more than 5 kilograms (P=0.04), end of treatment leukopenia ...details

International Journal of Medical Sciences Cover Page

Research Paper
Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less?
Hong Chang, Yi Gong, Jian Xu, Zhongxue Su, Chengkun Qin, Zhenhai Zhang
Int. J. Med. Sci. 2010, 7: 309-313
[Abstract] [Full text]

Research Paper
Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - A Meta-Analysis
Yaping Zhao, Furu Wang, Shunlin Shan, Yiqi Zhao, Xueming Qiu, Xiangyang Li, Feng Jiao, Jianguo Wang, Yunxiang Du
Int. J. Med. Sci. 2010, 7: 300-308
[Abstract] [Full text]

Research Paper
1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss
Min-shu Zou, Jian Yu, Guo-ming Nie, Wei-sun He, Li-man Luo, Hong-tao Xu
Int. J. Med. Sci. 2010, 7: 290-299
[Abstract] [Full text] [PDF]

Review
Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Disease
Ramin Ghazizadeh, Hajime Shimizu, Mamiko Tosa, Mohammad Ghazizadeh
Int. J. Med. Sci. 2010, 7: 284-289
[Abstract] [Full text] [PDF]

Research Paper
Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance
Jie Fang, Jian Ping Zhang, Cai Xia Luo, Xiao Mei Yu, Lan Qiu Lv
Int. J. Med. Sci. 2010, 7: 278-283
[Abstract] [Full text] [PDF]

Research Paper
Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis
Rui-dan Zheng, Cheng-run Xu, Li Jiang, Ai-xia Dou, Kun Zhou, Lun-gen Lu
Int. J. Med. Sci. 2010, 7: 272-277
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Treatment of oroantral fistula with autologous bone graft and application of a non-reabsorbable membrane
Adele Scattarella, Andrea Ballini, Felice Roberto Grassi, Andrea Carbonara, Francesco Ciccolella, Angela Dituri, Gianna Maria Nardi, Stefania Cantore, Francesco Pettini
Int. J. Med. Sci. 2010, 7: 267-271
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer
Kota Umemura, Shin-ichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Yoshiaki Ezaka, Kunihiko Nagasawa, Madoka Takahashi, Masahito Mizuuchi, Nanako Iwami, Hidefumi Adachi, Noriko Takeda, Mitsuharu Tamagawa, Tsuyoshi Saito
Int. J. Med. Sci. 2010, 7: 260-266
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain
Fei-xiang Wu, Jin-jun Bian, Xue-rong Miao, Sheng-dong Huang, Xue-wu Xu, De-jun Gong, Yu-ming Sun, Zhi-jie Lu, Wei-feng Yu
Int. J. Med. Sci. 2010, 7: 251-259
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Post-traumatic glioma: Report of one case and review of the literature
Bo Zhou, Weiguo Liu
Int. J. Med. Sci. 2010, 7: 248-250
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Surgical Management of Hidradenitis Suppurativa
Adnan Menderes, Ozgur Sunay, Haluk Vayvada, Mustafa Yilmaz
Int. J. Med. Sci. 2010, 7: 240-247
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats
Ibrahim A. Alsarra, Mahrous O. Ahmed, Fars K. Alanazi, Kamal Eldin Hussein ElTahir, Abdulmalik M. Alsheikh, Steven H. Neau
Int. J. Med. Sci. 2010, 7: 232-239
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression
Wei HE, Hao CHAI, Yingchun ZHANG, Shaohua YU, Wei CHEN, Wei WANG
Int. J. Med. Sci. 2010, 7: 224-231
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
Manfred Wiessler, Waldemar Waldeck, Ruediger Pipkorn, Christian Kliem, Peter Lorenz, Heinz Fleischhacker, Manuel Hafner, Klaus Braun
Int. J. Med. Sci. 2010, 7: 213-223
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
A case of mistaken identity: Asystole causing convulsions identified using implantable loop recorder.
Khalil Kanjwal, Beverly Karabin, Yousuf Kanjwal, Blair P Grubb
Int. J. Med. Sci. 2010, 7: 209-212
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects
Xiao-yan Liu, Li-ming Ruan, Wei-wei Mao, Jin-Qiang Wang, You-qing Shen, Mei-hua Sui
Int. J. Med. Sci. 2010, 7: 197-208
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Efficacy of Sirolimus-Eluting Stents Compared With Paclitaxel-Eluting Stents in an Unselected Population With Coronary Artery Disease: 24-Month Outcomes of Patients in a Prospective Non-randomized Registry in Southern Turkey
Davran Çiçek, Hasan Pekdemir, Nihat Kalay, Süleyman Binici, Hakan Altay, Haldun Müderrisoğlu
Int. J. Med. Sci. 2010, 7: 191-196
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
ISOLATION OF CHLAMYDIA PNEUMONIAE FROM SERUM SAMPLES OF THE PATIENTS WITH ACUTE CORONARY SYNDROME
Ivan M Petyaev, Nayilia A Zigangirova, Alexey M Petyaev, Ulia P Pashko, Lubov V Didenko, Elena U Morgunova, Yuriy K Bashmakov
Int. J. Med. Sci. 2010, 7: 181-190
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Maitake Mushroom Extracts Ameliorate Progressive Hypertension and Other Chronic Metabolic Perturbations in Aging Female Rats
Harry G. Preuss, Bobby Echard, Debasis Bagchi, Nicholas V. Perricone
Int. J. Med. Sci. 2010, 7: 169-180
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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