Int J Med Sci
2024; 21(4):690-702.
doi:10.7150/ijms.90261 This issueCite
Research Paper
Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways
Kai Yang✉, Zhi-Xiang Qi, Ming-Xin Sun, Li-Ping Xie
Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
✉ Corresponding author: Kai Yang, Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou, Zhejiang 310003, P.R. China. Tel.: +86-571-8723-6133; E-mail addresses: kaiyangedu.cn (Kai Yang).More
Citation:
Yang K, Qi ZX, Sun MX, Xie LP. Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways. Int J Med Sci 2024; 21(4):690-702. doi:10.7150/ijms.90261. https://www.medsci.org/v21p0690.htm
Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the proliferation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis of a few bladder cancer cells. Quantitative proteomics, bioinformatics analysis and Western blotting confirmed that hyperoside induced the overexpression of EGFR, Ras and Fas proteins, which affects a variety of synergistic and antagonistic downstream signaling pathways, including MAPKs and Akt, ultimately contributing to its anticancer effects in bladder cancer cells. This study reveals that hyperoside could be a promising therapeutic strategy for the prevention of bladder cancer.
Yang, K., Qi, Z.X., Sun, M.X., Xie, L.P. (2024). Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways. International Journal of Medical Sciences, 21(4), 690-702. https://doi.org/10.7150/ijms.90261.
ACS
Yang, K.; Qi, Z.X.; Sun, M.X.; Xie, L.P. Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways. Int. J. Med. Sci. 2024, 21 (4), 690-702. DOI: 10.7150/ijms.90261.
NLM
Yang K, Qi ZX, Sun MX, Xie LP. Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways. Int J Med Sci 2024; 21(4):690-702. doi:10.7150/ijms.90261. https://www.medsci.org/v21p0690.htm
CSE
Yang K, Qi ZX, Sun MX, Xie LP. 2024. Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways. Int J Med Sci. 21(4):690-702.
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