Int J Med Sci 2015; 12(9):719-726. doi:10.7150/ijms.12612 This issue Cite

Research Paper

Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q)

Rui Zhang1,2, Young-Mi Kim1, Xianfu Wang1, Yan Li2, Xianglan Lu1, Andrea R. Sternenberger1, Shibo Li1✉, Ji-Yun Lee3✉

1. Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
2. Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China
3. Department of Pathology, College of Medicine, Korea University, Seoul, South Korea.

Citation:
Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q). Int J Med Sci 2015; 12(9):719-726. doi:10.7150/ijms.12612. https://www.medsci.org/v12p0719.htm
Other styles

File import instruction

Abstract

The most common chromosomal abnormalities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are -5/del(5q) and -7/del(7q). When -5/del(5q) and -7/del(7q) coexist in patients, a poor prognosis is typically associated. Given that -5/del(5q) and/or -7/del(7q) often are accompanied with additional recurrent chromosomal alterations, genetic change(s) on the accompanying chromosome(s) other than chromosomes 5 and 7 may be important factor(s) affecting leukemogenesis and disease prognosis. Using an integrated analysis of karyotype, FISH and array CGH results in this study, we evaluated the smallest region of overlap (SRO) of chromosomes 5 and 7 as well as copy number alterations (CNAs) on the other chromosomes. Moreover, the relationship between the CNAs and del(5q) and -7/del(7q) was investigated by categorizing the cases into three groups based on the abnormalities of chromosomes 5 and 7 [group I: cases only with del(5q), group II: cases only with -7/del(7q) and group III: concurrent del(5q) and del(7q) cases]. The overlapping SRO of chromosome 5 from groups I and III was 5q31.1-33.1 and of chromosome 7 from groups II and III was 7q31.31-q36.1. A total of 318 CNAs were observed; ~ 78.3% of them were identified on chromosomes other than chromosomes 5 and 7, which were defined as 'other CNAs'. Group III was a distinctive group carrying the most high number (HN) CNAs, cryptic CNAs and 'other CNAs'. The loss of TP53 was highly associated with del(5q). The loss of ETV6 was specifically associated with group III. These CNAs or genes may play a secondary role in disease progression and should be further evaluated for their clinical significance and influence on therapeutic approaches in patients with MDS/AML carrying del(5q) and/or -7/del(7q) in large-scale, patient population study.

Keywords: MDS, AML, del(5q), -7/del(7q), Copy number alterations


Citation styles

APA
Zhang, R., Kim, Y.M., Wang, X., Li, Y., Lu, X., Sternenberger, A.R., Li, S., Lee, J.Y. (2015). Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q). International Journal of Medical Sciences, 12(9), 719-726. https://doi.org/10.7150/ijms.12612.

ACS
Zhang, R.; Kim, Y.M.; Wang, X.; Li, Y.; Lu, X.; Sternenberger, A.R.; Li, S.; Lee, J.Y. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q). Int. J. Med. Sci. 2015, 12 (9), 719-726. DOI: 10.7150/ijms.12612.

NLM
Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q). Int J Med Sci 2015; 12(9):719-726. doi:10.7150/ijms.12612. https://www.medsci.org/v12p0719.htm

CSE
Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY. 2015. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q). Int J Med Sci. 12(9):719-726.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image